Vaccine vectors and methods of enhancing immune responses
Abstract
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
Subject
A61P 31/16C12N 7/00
A61P 37/04
A61K 39/12
A61K 2039/6006
C12N 2760/16034
A61K 2039/543
A61K 48/00
A61K 2039/542
A61K 2039/523
A61K 2039/522
A61K 39/145
Collections
Citation
Berghman, Luc; Bottje, Walter; Hargis, Billy; Layton, Sherryll (2018). Vaccine vectors and methods of enhancing immune responses. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177236.