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dc.creatorHook, Magnus
dc.creatorKo, Ya-ping
dc.creatorSmeds, Emanuel
dc.creatorGanesh, Vannakambadi K.
dc.date.accessioned2019-06-17T17:06:48Z
dc.date.available2019-06-17T17:06:48Z
dc.date.issued2012-10-02
dc.identifier.urihttp://hdl.handle.net/1969.1/177006
dc.description.abstractThe present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen gamma-peptide; determining a ClfA binding region of the fibrinogen gamma-peptide; determining one or more critical amino acid residues in the ClfA binding region of a native fibrinogen gamma-peptide that is critical for a ClfA:fibrinogen gamma-peptide interaction; determining one or more amino acid residues of the ClfA that binds to the ClfA binding region of the native fibrinogen gamma-peptide; modeling the structure of the ClfA binding region; determining the structure of the ClfA in complex with the :fibrinogen gamma-peptide interaction; and identifying one or more potential agent(s) that inhibit the ClfA:fibrinogen gamma-peptide interaction without affecting binding of other proteins to the fibrinogen gamma-peptide.en
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.titleCrystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereofen
dc.typeUtility patenten
dc.format.digitalOriginreformatted digitalen
dc.description.countryUS
dc.contributor.assigneeThe Texas A & M University System
dc.identifier.patentapplicationnumber12/459327
dc.subject.uspcprimary702/19
dc.date.filed2009-06-30
dc.publisher.digitalTexas A&M University. Libraries
dc.subject.cpcprimaryC07K 16/1271
dc.subject.cpcprimaryA61K 38/363
dc.subject.cpcprimaryC07K 16/36
dc.subject.cpcprimaryG01N 33/68
dc.subject.cpcprimaryA61P 31/04
dc.subject.cpcprimaryC07K 16/18
dc.subject.cpcprimaryC07K 14/75
dc.subject.cpcprimaryC07K 14/31
dc.subject.cpcprimaryA61K 38/00
dc.subject.cpcprimaryG01N 2333/31
dc.subject.cpcprimaryG01N 2333/75


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