Decorin proteoglycan inhibitor of fibrinogen blood clotting
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The present invention provides compositions and methods of inhibiting fibrin(ogen) clot formation by utilizing decorin proteoglycan as an anticoagulating and antithrombotic agent. The decorin proteoglycan comprises a decorin core protein or a fragment thereof covalently linked to a galactosaminoglycan polysaccharide. The decorin core protein acts as an anticoagulant and as a carrier for the delivery of an antithrombotic galactosaminoglycan to fibrinogen. Fibrin clotting is inhibited by the decorin proteoglycan in a concentration-dependent fashion.
Höök, Magnus; Dugan, Tracey A. (2006). Decorin proteoglycan inhibitor of fibrinogen blood clotting. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from