Pneumatic nebulizing interface to convert an analyte-containing fluid stream into an aerosol, method for using same and instruments including same
Abstract
A self-adjusting, free-flowing pneumatic nebulizer interface is described for coupling fluid phase separation apparatus such as capillary electrophoresis apparatus or fluid-phase analyte delivery apparatus such as flow-injection analysis apparatus to gas phase, post-separation detection apparatus such as mass spectrometers, chemiluminescence detectors, or other similar gas phase detection apparatus. The interface combines the analytes with only the needed amount of sheath fluid to produce a combined flow whose magnitude automatically matches the self-aspiration rate of the pneumatic nebulizer interface, and which is combined with a gas flow to produce an aerosol. The resulting aerosol can then be either deposited directly on a surface, forwarded directly to a detection system or forwarded first to a conversion apparatus such as an oxidizer and the oxidized sample components are then forwarded to a detector.
Subject
436/127204/452
239/341
239/348
250/288
261/78.2
422/52
422/54
422/70
422/78
422/80
422/81
422/82.01
422/82.05
436/36
436/52
436/54
436/153
436/160
436/161
436/172
436/173
436/174
B05B 7/0408
B05B 7/064
B05B 7/066
G01N 27/44717
H01J 49/045
G01N 1/22
G01N 31/12
G01N 35/085
G01N 2030/8464
G01N 2030/847
Y10T 436/24
Y10T 436/20
Y10T 436/119163
Y10T 436/25
Y10T 436/117497
Collections
Citation
Vigh, Gyula; Sokolowski, Alex D. (2003). Pneumatic nebulizing interface to convert an analyte-containing fluid stream into an aerosol, method for using same and instruments including same. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176723.