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    Skeletal Impacts of Continuous Low-Dose-Rate Gamma Radiation Exposure During Simulated Microgravity

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    BOKHARI-DISSERTATION-2018.pdf (10.35Mb)
    Date
    2018-07-03
    Author
    Bokhari, Rihana
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    Abstract
    One of the greatest unknowns in human spaceflight is the effects of low-dose-rate galactic cosmic radiation (GCR). The majority of radiation studies deliver the total radiation dose expected on a 2-3 year mission in minutes. However, timing of radiation delivery is known to be biologically relevant. Very few studies have attempted to assess an appropriate timing, or doserate, of GCR exposure. We tested the effects of continuous low-dose-rate radiation (CIRR, dose rate of 6.25 mGy/day for 28 days) in combination with a slightly interrupted hindlimb unloading (iHU), simulated microgravity, and exercise treatments. CIRR alone led to few changes compared to the non-irradiated group. CIRR+iHU led to reductions in total body bone mineral density, lean mass, fat mass, cancellous bone volume and microarchitecture, and femoral neck ultimate load. Although exercise led to improvements in bone mass it was not able to mitigate losses when combined with CIRR and iHU. This indicates a differential response of bone to CIRR in combination with iHU. CIRR may not be detrimental to bone alone but further study is needed to understand the negative effects during iHU, which may not be rescuable by exercise. In the second experiment, we sought to assess how aging may affect the response to CIRR and HU in adult and middle-aged (astronaut aged) mice. Astronaut aged animals responded differently to CIRR and HU alone compared to adult animals. CIRR+HU diminished bone parameters beyond HU alone in both ages. Finally we conclude that young, skeletally mature animals may not be a good model for middle-aged crew members. Our results show that CIRR alone is not detrimental to bone, unlike what is normally found with acute radiation. Care on future missions should be taken to counter the combined detrimental effect of CIRR and unloading on bone. Our findings in different ages of mice suggest that the response to the combination of unloading and CIRR is conserved regardless of age and is therefore a continued life-long concern. The effects of space relevant radiation on bone continue to be a concern for future spaceflight missions, especially exploration class missions to the moon and Mars.
    URI
    https://hdl.handle.net/1969.1/173898
    Subject
    Bone
    Radiation
    Low-dose-rate
    Hindlimb unloading
    Disuse
    Spaceflight
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    • Electronic Theses, Dissertations, and Records of Study (2002– )
    Citation
    Bokhari, Rihana (2018). Skeletal Impacts of Continuous Low-Dose-Rate Gamma Radiation Exposure During Simulated Microgravity. Doctoral dissertation, Texas A & M University. Available electronically from https : / /hdl .handle .net /1969 .1 /173898.

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