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The Effect of Phosphorylated Glucose on Major Pathogens of Bovine Mastitis
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Mastitis is the number one infectious disease on dairies. Treatment and prevention is mainly through good milking hygiene, proper environmental conditions, and antibiotic usage. For organic dairies, mastitis prevention and control can be problematic as there are major restrictions on the use of antibiotics. Phosphorylated glucose, produced by heating (121ºC) a phosphate-buffered solution with added glucose, is bactericidal to Escherichia coli. We tested the bactericidal properties of phosphorylated glucose on three major pathogens of mastitis: E. coli, Staphylococcus aureus, and Streptococcus agalactiae. Phosphorylated glucose was bactericidal on the pathogens tested in phosphate-buffered saline. When in the presence of milk, phosphorylated glucose was not bactericidal on E. coli, but Staph. aureus and Strep. agalactiae are still affected. Further studies of phosphorylated glucose on Mycoplasma, a pathogen of mastitis that is inherently resistant to β-lactam antibiotics, and on mammary cells are in process. This work will provide organic dairy producers with additional information for the prevention and treatment of mastitis.
Schaefer, Kendall H (2017). The Effect of Phosphorylated Glucose on Major Pathogens of Bovine Mastitis. Undergraduate Research Scholars Program. Available electronically from