Prevention Of Spontaneous Tumors By Pharmacological Inhibition Of The Epidermal Growth Factor Receptor
Abstract
The epidermal growth factor receptor (EGFR) is a ligand-activated tyrosine kinase receptor that is often overexpressed in cancers and plays a significant role in cell proliferation and inhibition of apoptosis. Mouse model studies have demonstrated the ability of EGFR inhibition to hinder spontaneous colorectal cancer occurrence by 50-80% when EGFR inhibition is induced before the establishment of tumors (Rinella, ES and Threadgill, DW doi 10.1371/journal.pone.0039552). The success rates reported in human clinical trials differ from mouse model studies, with a 15% success rate among colorectal cancer patients receiving anti-EGFR treatment (Pritchart CC, and Grady WM doi 10.1136/gut.2009.206250). Timing of treatment is the major difference between animal/mouse trials and human therapeutic treatment of end-stage cancers. In our study, it was hypothesized that earlier preventative doses of the AG1478 chemotherapy inhibitor would reduce the frequency of spontaneous tumor occurrence in a preventative, rather than therapeutic, manner in a murine population. This current study provides additional specificity and histopathological analysis of the spontaneous tumor occurrence in a large murine sample of four genetically distinct wild-type strain mice to better simulate a variable human population. Such specificity includes, but is not limited to, the number, type and severity of the tumors that did occur and whether the concentration of the drug is correlated to a reduction in tumor occurrence. Such information will broaden the discussion of EGFR’s role in tumor treatment.
Subject
EGFREGFR inhibition
Chemotherapy
Preventative Chemotherapy
Tumor treatment
Murine
Murine Tumor
Epidermal Growth Factor
AG1478
Tyrphostin AG1478
AG1478 inhibitor
AG1478 efficacy
Efficacy
Histology
Histopathology
Histopathological
Adenoma
Pulmonary adenoma
Hyperplasia
White pulp hyperplasia
Hypoplasia
White pulp hypoplasia
Sarcoma
Soft tissue sarcoma
Citation
Eichner, Jared Hart (2019). Prevention Of Spontaneous Tumors By Pharmacological Inhibition Of The Epidermal Growth Factor Receptor. Undergraduate Research Scholars Program. Available electronically from https : / /hdl .handle .net /1969 .1 /166532.