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dc.creatorRoth, Abigail A
dc.date.accessioned2018-05-23T15:34:39Z
dc.date.available2018-05-23T15:34:39Z
dc.date.created2019-05
dc.date.submittedMay 2019
dc.identifier.urihttp://hdl.handle.net/1969.1/166494
dc.description.abstractWithin cranial bone defect treatments, autografts remain the current gold standard for best healing outcomes. However, if the defect is of a unique shape, this process proves difficult and often requires additional surgeries. The work herein focuses on a regenerative approach utilizing a shape memory polymer (SMP) scaffold that can "self-fit" into a defect while maintaining important properties for healing (e.g. osteoconductivity, robustness, degradability). Poly(ε-caprolactone) (PCL) is an extensively studied SMP but, alone, is limited in bone repair due to its relatively low modulus and slow degradation rate for adequate bone healing.[1-3] To improve these properties, our group reported SMPs comprised of a semi-interpenetrating network (semi-IPN) of cross-linked PCL diacrylate (PCL-DA) and poly(L-lactic acid) (PLLA), which have shown great potential.[4, 5] Here, we investigated the degradation behavior of porous PCL-PLLA semi-IPN SMP implants in vitro under both accelerated conditions and non-accelerated conditions towards ultimately predicting in vivo performance. Rapid degradation with greater PLLA wt% content was observed, along with mass losses up to ~9% at 5 months real-time degradation. Additionally, degradation was unaffected by the compressed implant "fitting" process, yet slightly accelerated by the application of a bioactive surface coating.en
dc.format.mimetypeapplication/pdf
dc.subjectshape memory polymeren
dc.subjectSMPen
dc.subjectin vitro degradationen
dc.subjectcranial defectsen
dc.titleAssessment of Degradation for Porous PCL-PLLA Semi-IPN Shape Memory Polymer (SMP) Implants for Cranial Defect Repairen
dc.typeThesisen
thesis.degree.departmentBiomedical Engineeringen
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorUndergraduate Research Scholars Programen
thesis.degree.nameBSen
thesis.degree.levelUndergraduateen
dc.contributor.committeeMemberGrunlan, Melissa A
dc.type.materialtexten
dc.date.updated2018-05-23T15:34:41Z


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