Browsing by Subject "oxidative stress"
Now showing items 1-14 of 14
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Cytotoxicological Response to Engineered Nanomaterials: A Pathway-Driven Process
(2012-07-16)Nanoparticles, while included in a growing number of consumer products, may pose risks to human health due to heavy metal leaching and/or the production of reactive oxygen species following exposures. Subcellular mechanisms ... -
Differential expressions of cell cycle regulatory proteins and ERK1/2 characterize the proliferative smooth muscle cell phenotype induced by allylamine
(Texas A&M University, 2004-09-30)Chronic oxidative injury by allylamine induces proliferative vascular smooth muscle cell (vSMC) phenotypes in the rat aorta similar to those seen in rodent and human atherosclerotic lesions. In this study, we evaluate the ... -
Dysregulation of nuclear factor kappa B activity and osteopontin expression in oxidant-induced atherogenesis
(Texas A&M University, 2004-09-30)NF-κB activity is critical in the regulation of atherosclerotic vascular smooth muscle cell (vSMC) phenotypes induced following oxidative injury by allylamine. The present studies were designed to detail dysregulation of ... -
Effect of Antioxidant Gel on Oxidative Stress and Salivary Flow Rate in Xerostomic Patients
(2017-04-28)This study was designed to observe the effects of an antioxidant gel on oxidative stress levels and salivary flow rates in xerostomic patients. In this prospective, nested, double blind, crossover, randomized clinical ... -
Effects of dietary fat and fiber on the oxidative status of the small intestine and colon of rats
(Texas A&M University, 2006-08-16)Colon cancer is one of the most commonly diagnosed cancers in the US, yet small intestine cancer is a rare event. While there are many similarities between these two tissues, inherent differences such as redox status, may ... -
Effects of High Dietary Iron and Gamma Radiation on Oxidative Stress and Bone
(2013-04-19)Astronauts in space flight missions are exposed to increased iron (Fe) stores and galactic cosmic radiation, both of which independently induce oxidative stress. Oxidative stress can result in protein, lipid, and DNA ... -
Effects of Radiation, Diet, and Microgravity on Colonocyte Gene Expression
(2017-05-25)Recent progress has been made in understanding the physiological responses to conditions prevalent in the space flight environment, including radiation source, duration of radiation exposure, weightlessness, and diet. The ... -
Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals
(2017-12-09)In recent years, there has been increased interest into better understanding how environmental In recent years, there has been increased interest into better understanding how environmental exposures influence the long-term ... -
An evaluation of the impacts of aging on skeletal muscle performance in several mammalian divers
(2009-05-15)Based on the ‘free radical theory of aging,’ I hypothesized that hypoxia caused by the mammalian dive response induces free radical production which could modulate or accelerate cellular aging. On the other hand, to prevent ... -
Identification and molecular characterization of novel genomic targets in oxidant-induced vascular injury
(Texas A&M University, 2007-04-25)Gene expression was examined in vascular smooth muscle cells to study the complex interaction between oxidative injury and the pathogenesis of vascular disease. Extensive vascular remodeling coupled to increased production ... -
Membrane Oxidation Governed Direct Plasma Membrane Translocation of Cell-Penetrating Peptides in Live Cells: Mechanisms and Implications
(2016-08-03)Cell-penetrating peptides (CPPs) enter cells primarily through escaping from endosomal compartments or directly translocating across the plasma membrane. Due to their capability of permeating into the cytosolic space of ... -
Proteomics of Oxidative Stress Using Inducible CYP2E1 Expressing HepG2 Cells and 3T3-L1 Adipocytes as Model Systems
(2012-07-16)The overall goal of this research was to investigate oxidative stress related changes to the proteomes of 3T3-L1 adipocytes and an inducible CYP2E1 expressing HepG2 cells. Enhanced oxidative stress in hypertrophic adipocytes ... -
The Pro-Antioxidant Role of Zinc Supplementation in Cadmium-Treated Choroid Plexus
(2014-05-06)Cadmium (Cd) is a toxic heavy metal with no known physiological function in higher order animals. Previous studies in primary cultures of neonatal rat choroid plexus (CP) epithelial cells indicated Cd induced oxidative ... -
The Use of Anti-Oxidants in the Treatment of Persistent, Non-Responsive Oral Lichen Planus: A Randomized Control Clinical Trial
(2015-04-29)Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology. Typical management of OLP involves topical corticosteroids. Recent literature shows an association between high levels of various oxidative ...