Browsing by Subject "Sp transcription factors"
Now showing items 1-3 of 3
-
Diindolylmethane Analogs as Novel NR4A1 Antagonists and as a Novel Class of Anticancer Agents and Sp Transcription Factors as Nononcogene Addiction Genes That Are Targets of ROS Inducing Agents
(2016-12-13)The orphan nuclear receptor 4A1 (NR4A1) and specificity protein (Sp) transcription factors (TFs) are both overexpressed in the majority of solid tumors. Our laboratory has researched the molecular mechanisms of a novel ... -
New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers
(2011-08-08)Methyl 2-cyano-3,11-dioxo-18b-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic triterpenoid that inhibits growth of Panc1 and Panc28 pancreatic cancer cell lines and activates peroxisome proliferator-activated receptor B ... -
Phenethyl Isothiocyanate (PEITC) Decreases Specficity Protein (SP) Tanscription Factors through an ROS-dependent Mechanism
(2012-12-05)Isothiocyanates (ITCs) are phytochemicals highly expressed in cruciferous vegetables and these compounds are associated with the decreased incidence of cancers in populations consuming high levels of cruciferous vegetables. ...