Browsing by Subject "Mitochondria"
Now showing items 1-16 of 16
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(2022-10-20)Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by progressive motor dysfunction and currently has no cure. Research has elucidated coalescing molecular dysfunctions including neuroinflammation, ...
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(2011-08-08)An integrative biophysical and bioanalytical approach to studying the Fe distribution in isolated mitochondria was developed. This procedure involved large-scale growths, the inclusion of a chelator in isolation buffers ...
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(2019-07-23)Research regarding factors that impact musculoskeletal characteristics of horses is sparse. Therefore, we conducted four experiments to assess potential effects of breed, exercise training, complexed trace mineral ...
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(2021-12-16)Copper is an essential micronutrient that is used as a cofactor for enzymes involved in diverse cellular processes including mitochondrial respiration and iron transport. However, free copper is highly reactive and deleterious ...
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(2021-04-27)Astrocytes are the most populous cell type in the central nervous system (CNS) and are vital in neuron development, regulating blood flow, and maintaining communication between neurons. Astrocytic control on the CNS is due ...
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(2014-04-08)Mitochondria house the mitochondrial respiratory chain (MRC), the main site for cellular respiration and energy production. The MRC consists of five large protein complexes (I-V) in the inner mitochondrial membrane. Despite ...
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(2017-06-16)Mitochondria contain a low-molecular-mass (LMM) pool of weakly bound iron complexes, called the labile iron pool (LIP). Although its composition and biological function remain largely uncharacterized, the LIP has been ...
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(2013-11-27)Transition metals play essential roles in biological systems, but Fe can also be toxic to cells. In order to maintain this balance between necessity and toxicity mechanisms are employed for regulating and storing intracellular ...
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The role mitochondria play in mammary gland development is not fully understood and therefore provides an interesting opportunity to study novel interactions. The purpose of this project is to elucidate unknown cellular ...
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(2023-06-22)Stroke is a leading cause of death and long-term disability in the United States. Women over the age of 55 have a higher lifetime risk of stroke and worse outcomes after stroke compared to men of the same age[1]. However, ...
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(PLOS, 2015-04-30)Adaptation and survival of Trypanosoma brucei requires editing of mitochondrial mRNA by uridylate (U) insertion and deletion. Hundreds of small guide RNAs (gRNAs) direct the mRNA editing at over 3,000 sites. RNA editing ...
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(2018-05-03)NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is crucial for activation of the non-canonical NF-κB signaling pathway. Although NIK has been shown to promote tumorigenesis in ...
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(2022-09-20)Dysregulation of cellular metabolism is a defining hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. The mechanisms by which cells undergo the switch from respiration to ...
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(2017-05-01)The mitochondrial respiratory chain (MRC) consists of four large protein complexes that catalyze redox reactions driving cellular energy production. These complexes assemble into supra-molecular structures called supercomplexes ...
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(Texas A&M University, 2005-11-01)Colon cancer is the second leading cause of cancer death in the United States. Epidemiological data indicate that the consumption of dietary fiber and fish/marine products favorably modulate colon tumorigenesis. Docosahexaenoic ...
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(2022-10-31)Mitophagy has become an increasingly important topic for addressing pathologies of neurodegenerative disease. Yet there is still much to be understood about the key players that regulate mitophagy as well as its involvement ...