Browsing by Department "College of Medicine"
Now showing items 1-20 of 168
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(2022-01-12)Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria. The composition of commensal bacterial species can thus shift in response to changes in host dietary nutrient availability, ...
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(2015-05-05)Angelman syndrome (AS), chromosome 15q11-q13 duplication syndrome (Dup15q), and Prader-Willi syndrome (PWS) are neurodevelopmental disorders associated with dysregulated expression of imprinted genes located within the ...
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(2014-01-14)Endothelial cell (EC) junctions are critical for angiogenesis, the sprouting and growth of new blood vessels from existing vessels. Sphingosine 1-phosphate (S1P) is a proangiogenic factor that potently stimulates sprouting, ...
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(2018-05-03)Peroxisomes are single membrane-bound and autonomously replicating subcellular organelles. While their function as metabolic organelles is well known, their place in the world of cell signaling is only just beginning to ...
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(2017-12-06)Hepatocellular carcinoma (HCC) is the most common type of human liver cancer and it is now the second leading cause of cancer death worldwide. In the United States, its incidence has tripled since 1980 and the death rates ...
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(2017-04-21)The mechanisms by which the immune system distinguishes self from non-self are essential in providing protection from pathogenic invaders and to prevent autoimmunity. Over the last few decades, the discovery of regulatory ...
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(2021-08-09)Antimicrobial resistance (AMR) in pathogenic bacteria is increasing worldwide. One solution to this crisis is bacteriophage therapy, a treatment which harnesses naturally occurring bacterial viruses to invade and lyse AMR ...
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(2022-05-05)Bioreactor-mediated expansion of human mesenchymal stem cells (hMSCs) is a promising technique for the generation of hMSCs and their secreted products for immunoregulation therapies at scales required for use in the clinic. ...
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(2014-08-04)Congenital heart diseases (CHD) are the leading cause of infant mortality and morbidity. Defects of the outflow tract (OFT) make up a large percentage of human CHD. In my study, I focused on the role of Bone morphogenetic ...
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(2022-11-07)Blos1 is a novel immune defense factor that defends against bacterial and viral infections, and Brucella and coronaviruses subvert this innate immune defense to promote infection. Here we show Blos1 as a novel immune defense ...
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(2019-03-27)Epilepsy is a chronic neurological disorder characterized by unpredicted recurrent seizures. Dysfunction of GABA-A receptors (GABA-ARs) in the brain plays a key role in the pathophysiology of epilepsy. Neurosteroids are ...
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(2017-02-16)Mycobacterium marinum is a medically important aquatic pathogen that causes cutaneous granulomatous lesions in humans and a chronic tuberculosis-like granulomatous disease in ectotherms. M. marinum is commonly used as a ...
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(2019-04-18)Membrane proteins interact intimately with the lipid bilayer in which they are embedded. Interactions between membrane proteins and ligands such as lipids and other small molecules can affect protein structure and function. ...
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(2019-08-06)The nucleus is the brain of the cell and is the site of regulation of processes such as DNA replication, transcription and cell cycle. Given its importance in cell function, several known bacterial proteins have been shown ...
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(2017-08-07)Proteins must be translocated from ribosomes where they are synthesized to different cellular destinations where they perform their functions. Many different protein translocation systems carry out this activity like the ...
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(2023-07-10)Mitochondria are pleiotropic organelles integral to many processes including energy generation, cell death, signal transduction, and immunity. Consequently, mitochondrial dysfunction can significantly alter cell and tissue ...
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(2023-07-10)Mitochondria are pleiotropic organelles integral to many processes including energy generation, cell death, signal transduction, and immunity. Consequently, mitochondrial dysfunction can significantly alter cell and tissue ...
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(2014-08-28)The complement system, a major component of the innate immunity, is critical for combating microbial infections. It can be activated by three distinct pathways: the classical pathway, the lectin pathway and the alternative ...
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(2021-07-06)The human cell-free DNA (cfDNA) methylation profile in liquid biopsy has been utilized to diagnose early-stage disease and estimate therapy response. However, typical clinical procedures are capable of purifying only very ...
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(2016-08-02)Lyme disease is a significant and re-emerging disease that impacts the public health, particularly in endemic regions. The causative agent of Lyme disease, Borrelia burgdorferi, is transmitted to humans by Ixodes ticks. ...