Chronic inflammatory enteropathy (CIE) is a common cause of gastrointestinal signs in dogs, but its etiology is poorly understood. Dogs with CIE have imbalances in their bile acid (BA) metabolism and gastrointestinal ...

Controlling metastatic and invasive tumors is the challenging part of treating cancer. The overall aim of this dissertation was to target these aggressive cells, called tumor-initiating cells (TICs). They exploit embryonic ...

Ferrets are valuable animal models for the study of many human diseases. Cystic fibrosis (CF) and pancreatitis are two such human diseases that could benefit from a ferret model. The pancreatic disease processes that occur ...

Inflammatory bowel disease (IBD) is a common condition in dogs that is challenging to diagnose. A dysregulated innate immunity plays a major role in its pathogenesis, and surrogate inflammatory markers that reflect disease ...

Chronic gastrointestinal disease in dogs can manifest itself in many different ways including vomiting, diarrhea, and weight loss. Bile acid dysmetabolism has recently been recognized as an important component of chronic ...

Chronic hepatitis can present a diagnostic challenge, with different types of chronic hepatic disease being associated with similar clinical and laboratory findings. Clinical signs of chronic hepatitis are often non-specific; ...

Ulcerative colitis is a chronic inflammation of the large intestine, and it may increase risk of human colorectal cancer. Polyphenolics from mango and pomegranate have been shown to have potent anti-inflammatory properties, ...

Gene-environment interactions can be efficiently estimated in case-control data by existing retrospective methods that assume gene-environment independence in the source population, but such techniques require parametric ...