Browsing by Author "Suchodolski, Jan S"
Now showing items 1-19 of 19
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Adaptation and Analytical Validation of a Radioimmunoassay for the Measurement of Human Cholecystokinin for Use in Dogs
Lagutchik, Stephen Christopher (2014-04-22)Cholecystokinin (CCK) is an important neuroendocrine peptide in the gastrointestinal tract, being the major stimulant for exocrine pancreatic secretion and gall bladder contraction. As such, cholecystokinin release may be ... -
Bile Acid Metabolism and Gastrointestinal Microbiota in Dogs with Chronic Inflammatory Enteropathy
Giaretta, Paula Roberta (2019-04-04)Chronic inflammatory enteropathy (CIE) is a common cause of gastrointestinal signs in dogs, but its etiology is poorly understood. Dogs with CIE have imbalances in their bile acid (BA) metabolism and gastrointestinal ... -
Canine Chronic Hepatitis: Diagnostic Evaluation and Complicating Syndromes
Lidbury, Jonathan Andrew (2015-11-13)Chronic hepatitis is an important disease in dogs that can lead to hepatic fibrosis, portal hypertension, and hepatic encephalopathy. Histological assessment of liver biopsy specimens is currently required to definitively ... -
Characterization and Inhibition of Canine Osteosarcoma Tumor-Initiating Cells
Pfent, Catherine Marie (2015-11-02)Controlling metastatic and invasive tumors is the challenging part of treating cancer. The overall aim of this dissertation was to target these aggressive cells, called tumor-initiating cells (TICs). They exploit embryonic ... -
Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei – Evaluation of a Potential Hereditary Etiology
Grützner, Niels (2013-12-11)In recent history, no other dog breed has grown in popularity and/or population size in such a short period of time as is the case for the Chinese Shar Pei in North America. After being introduced to North America in the ... -
Development and Analytical Validation of a Radioimmunoassay for the Measurement of Trypsin-like Immunoreactivity in Ferret Serum
Bridges, Cory Seth (2017-01-04)Ferrets are valuable animal models for the study of many human diseases. Cystic fibrosis (CF) and pancreatitis are two such human diseases that could benefit from a ferret model. The pancreatic disease processes that occur ... -
The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing
Suchodolski, Jan S; Dowd, Scot E; Westermarck, Elias; Steiner, Jörg M; Wolcott, Randy D; Spillmann, Thomas; Harmoinen, Jaana A (BMC Microbiology, 2009) -
Evaluation of Canine S100A12 and sRAGE as Novel Disease
Heilmann, Romy Monika (2015-04-24)Inflammatory bowel disease (IBD) is a common condition in dogs that is challenging to diagnose. A dysregulated innate immunity plays a major role in its pathogenesis, and surrogate inflammatory markers that reflect disease ... -
Impact of diets with a high content of greaves-meal protein or carbohydrates on faecal characteristics, volatile fatty acids and faecal calprotectin concentrations in healthy dogs
Hang, Ingrid; Heilmann, Romy M; Grützner, Niels; Suchodolski, Jan S; Steiner, Jörg M; Atroshi, Faik; Sankari, Satu; Kettunen, Anu; de Vos, Willem M; Zentek, Jürgen; Spillmann, Thomas (BMC Veterinary Research, 2013) -
Microbial Characterization, Metabolomic Profiling, and Bile Acid Metabolism in Healthy Dogs and Dogs with Chronic Enteropathy
Guard, Blake Crosby (2017-06-23)Chronic gastrointestinal disease in dogs can manifest itself in many different ways including vomiting, diarrhea, and weight loss. Bile acid dysmetabolism has recently been recognized as an important component of chronic ... -
Microbiota and Metabolomic Changes Across Various Canine Gastrointestinal Diseases
Honneffer, Julia Beth (2017-05-30)The canine gastrointestinal tract (GIT) is home to a complex ecosystem known as the microbiome. The microbiota (i.e., bacteria, viruses, fungi, and protozoa) are metabolically active, augmenting host digestion and thereby ... -
Novel Biomarker Discovery in Dogs with Chronic Hepatitis
Lawrence, Yuri Alexander (2019-02-28)Chronic hepatitis can present a diagnostic challenge, with different types of chronic hepatic disease being associated with similar clinical and laboratory findings. Clinical signs of chronic hepatitis are often non-specific; ... -
Novel lipoprotein density profiling in healthy dogs of various breeds, healthy miniature schnauzers, and miniature schnauzers with hyperlipidemia
Xenoulis, Panagiotis G; Cammarata, Paul J; Walzem, Rosemary L; Macfarlane, Ronald D; Suchodolski, Jan S; Steiner, Jörg M (BMC Veterinary Research, 2013) -
Polyphenolics from Mango (Mangifera indica L.) and Pomegranate (Punica granatum L.) Suppress Inflammation in in vivo and in vitro Models for Colitis
Kim, Hye Mee (2013-12-11)Ulcerative colitis is a chronic inflammation of the large intestine, and it may increase risk of human colorectal cancer. Polyphenolics from mango and pomegranate have been shown to have potent anti-inflammatory properties, ... -
Salmonella and Multidirectional Communication in the Gut
Gart, Elena Vladimirovna (2017-04-24)Salmonella enterica serovar Typhymurium (S. Typhimurium) is a bacterial pathogen which is a cause of over a million cases of gastrointestinal illness worldwide. The GI tract is a large and complex environment influenced ... -
Semiparametric Analysis of Complex Polygenic Gene-Environment Interactions in Case-Control Studies
Asher, Alexander Allen (2018-08-07)Gene-environment interactions can be efficiently estimated in case-control data by existing retrospective methods that assume gene-environment independence in the source population, but such techniques require parametric ... -
Serum and Fecal Markers of Chronic Lymphocytic Enteritis in the Common Marmoset (Callithrix Jacchus)
Joseph Cyrus, FNU (2018-05-17)Chronic lymphocytic enteritis (CLE) is a fatal condition in the common marmoset (C. jacchus) and is characterized by hypoalbuminemia. Fecal alpha1-proteinase inhibitor (α₁-PI) concentrations can be used to diagnose enteric ... -
Stability of 3-bromotyrosine in serum and serum 3-bromotyrosine concentrations in dogs with gastrointestinal diseases
Sattasathuchana, Panpicha; Grützner, Niels; Lopes, Rosana; Guard, Blake C; Suchodolski, Jan S; Steiner, Jörg M (BMC Veterinary Research, 2015) -
Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies
Anfinsen, Kristin P; Berghoff, Nora; Priestnall, Simon L; Suchodolski, Jan S; Steiner, Jörg M; Allenspach, Karin (Acta Veterinaria Scandinavica, 2014)