Browsing by Author "Sacchettini, James"
Now showing items 1-20 of 43
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A Biophysical Approach to Investigate the Human Fe-S Cluster Assembly Pathway
Fox, Nicholas G (2014-06-02)Iron sulfur (Fe-S) clusters are essential cofactors that function in electron transport, catalyzing substrate turnover, environmental sensing, and initiating radical chemistry. Elaborate multi-component systems have evolved ... -
Catalytic Promiscuity and the Evolutionary Mechanism of NSAR Reaction Specificity in the NSAR/OSBS Subfamily
Truong, Dat Phuoc (2020-03-06)Catalytic promiscuity is the coincidental ability for an enzyme to catalyze nonbiological reactions in the same active site as the native biological reaction. Several lines of evidence show that catalytic promiscuity plays ... -
Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors
Wu, Fei (2009-05-15)Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ERα. The compounds investigated in this study include 17β-estradiol (E2), ... -
Complex Organization and Dynamic Regulation of the pks Gene Cluster in Bacillus subtilis
Vargas Bautista, Carol M (2014-08-27)The pks genes are the largest antibiotic- encoding gene cluster in Bacillus subtilis and encode the Pks enzymatic complex that produces bacillaene. Bacillaene plays important roles in the fitness of B. subtilis during ... -
Compositions and methods for drug-sensitization or inhibition of a cancer cell
Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2017-01-10)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ... -
Compositions and methods for drug-sensitization or inhibition of a cancer cell
Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2015-09-15)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ... -
Compositions and methods for drug-sensitization or inhibition of a cancer cell
Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2018-01-16)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ... -
Crystal Structures of Binary and Ternary Complexes of Thymidylate Synthase (ThyA) from Mycobacterium tuberculosis: Insights into Selectivity and Inhibition
Harshbarger, Wayne (2012-10-19)Thymidylate synthase (TS), encoded by the ThyA gene, is essential for the growth and survival of Mycobacterium tuberculosis and therefore is a potential drug target. Thymidylate synthase binds both a substrate, ... -
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32
Stanley, Sarah; Kawate, Tomohiko; Iwase, Noriaki; Shimizu, Motohisa; Clatworthy, Anne; Kazyanskaya, Edward; Sacchettini, James; Ioerger, Thomas; Siddiqi, Noman; Minami, Shoko; Aquadro, John; Sarah Schmidt Grant; Rubin, Eric; Hung, Deborah (Proceedings of the National Academy of Sciences of the United States of America, 2013) -
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Andrés Palencia; Li, Xianfeng; Bu, Wei; Choi, Wai; Ding, Charles; Easom, Eric; Feng, Lisa; Hernandez, Vincent; Houston, Paul; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Rock, Fernando; Sexton, Holly; Zhang, Suoming; Zhou, Yasheen; Wan, Baojie; Wang, Yuehong; Franzblau, Scott; Woolhiser, Lisa; Gruppo, Veronica; Lenaerts, Anne; Theresa O'Malley; Parish, Tanya; Cooper, Christopher; M. Gerard Waters; Ma, Zhenkun; Ioerger, Thomas; Sacchettini, James; Joaquín Rullas; Iñigo Angulo-Barturen; Esther Pérez-Herrán; Mendoza, Alfonso; Barros, David; Cusack, Stephen; Plattner, Jacob; M. R. K. Alley (Antimicrobial Agents and Chemotherapy, 2016) -
Dissolution Dynamic Nuclear Polarization of Polypeptides
Ragavan, Mukundan (2014-06-27)Nuclear Magnetic Resonance (NMR) spectroscopy provides remarkable site resolution, but often requires signal averaging because of low sensitivity. Dissolution dynamic nuclear polarization (DNP), which offers large signal ... -
Fragment Based Protein Active Site Analysis Using Markov Random Field Combinations of Stereochemical Feature-Based Classifications
Pai Karkala, Reetal (2010-07-14)Recent improvements in structural genomics efforts have greatly increased the number of hypothetical proteins in the Protein Data Bank. Several computational methodologies have been developed to determine the function of ... -
Genetic Approaches to Regulation and Identification of Bacterial Specialized Metabolites
Zhang, Chengxi (2020-07-30)In natural habitats, microorganisms synthesize specialized metabolites and enzymes that mediate chemical interactions between organisms. Those natural products have various biological activities, acting as signaling ... -
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
Ioerger, Thomas; Theresa O’Malley; Liao, Reiling; Guinn, Kristine; Hickey, Mark; Mohaideen, Nilofar; Murphy, Kenan; Boshoff, Helena; Mizrahi, Valerie; Rubin, Eric; Sassetti, Christopher; Barry, Clifton; III; Sherman, David; Parish, Tanya; Sacchettini, James (PloS One, 2013) -
The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling
Hong, Wei; Wang, Yu; Chang, Zhe; Yang, Yanhui; Pu, Jing; Sun, Tao; Kaur, Sargit; Sacchettini, James; Jung, Hunmin; Wee Lin Wong; Lee Fah Yap; Yun Fong Ngeow; Paterson, Ian; Wang, Hao (Scientific Reports, 2015) -
Identification of Pks13 Inhibitors for Antitubercular Drug Discovery
Leon Quinonez, StephanieFrontline tuberculosis drugs, i.e. Isoniazid, have become inefficient as strains of Mycobacterium Tuberculosis have become multi-drug resistant, creating an urgent need for novel antitubercular drugs. The key to the bacterium ... -
Identification of Whole Cell Active Molecules of Mycobacterium Tuberculosis, Elucidation of Molecular Mechanisms Responsible for Resistance, and Characterization of Rv0272: A potential Therapeutic Target
Hughes, Ryan C (2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ... -
Identifying and Characterizing Molecular Parameters that Modulate the Endosomal Escape of Cationic Cell- Penetrating Peptides: A Structure Activity Approach
Najjar, Kristina (2017-07-13)For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting macromolecules (cargos) into live cells for cell biology manipulations and therapeutic applications. While the exact ... -
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach
Pai, Reetal; Sacchettini, James; Ioerger, Thomas (Acta Crystallographica. Section D - Biological Crystallography, 2006) -
Mechanism of thioamide drug action against tuberculosis and leprosy
Wang, Feng; Langley, Robert; Gulten, Gulcin; Dover, Lynn; Besra, Gurdyal; Jacobs, William; Jr.; Sacchettini, James (The Journal of Experimental Medicine, 2007)