Browsing by Author "Mwangi, Waithaka"
Now showing items 1-20 of 28
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Adenovirus-vectored novel African Swine Fever Virus antigens elicit robust immune responses in swine
Lokhandwala, Shehnaz; Waghela, Suryakant; Bray, Jocelyn; Sangewar, Neha; Charendoff, Chloe; Martin, Cameron; Hassan, Wisam; Koynarski, Tsvetoslav; Gabbert, Lindsay; Burrage, Thomas; Brake, David; Neilan, John; Mwangi, Waithaka (PloS One, 2017) -
Antibodies Targeting Poly-N-Acetyl Glucosamine Protect Against the Intracellular Pathogen, Rhodococcus Equi
Rocha, Joana Nunes (2018-11-21)Rhodococcus equi is a facultative intracellular pathogen that causes pyogranulomatous pneumonia in foals <6 months of age. Why foals are highly susceptible to R. equi is unknown. R. equi pneumonia is a leading cause of ... -
Babesia microti Recombinant DNA Vaccine as a Model for Babesia bovis Prevention
Carroll, Juliette E. (2011-02-22)Babesiosis is caused by a genus of tick-transmitted apicomplexan parasites with considerable economic, medical, and veterinary impact. Bovine babesiosis is an important impediment to livestock production throughout the ... -
Basic and Applied Aspects of Chicken Macrophage Biology
Chou, Wen-Ko (2013-11-26)The best way to prevent infectious disease is to directly establish mucosal immunity and also induce circulatory immunity to avoid pathogen invasion and spread. In our first study, we tested the hypothesis that a single ... -
Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant
Martin, Cameron Lee (2017-05-10)Lack of safe and effective adjuvants is a major hindrance to the development of efficacious vaccines. Signaling via CD40 pathway leads to enhanced antigen processing and presentation, nitric oxide expression, pro-inflammatory ... -
Cloning and expression of equine NF-kB2
Mirhosseini, Negin (2009-05-15)Equine infectious anemia virus (EIAV) is a macrophage-tropic retrovirus that causes persistent disease in horses and ponies. In addition to its structural proteins, EIAV encodes four regulatory/accessory genes, tat, rev, ... -
Development of a Novel, Peptide-based Vaccine for Lyme Disease
Brock, Christina Marie (2017-07-28)Lyme disease (LD) is the most prevalent arthropod borne illness in the US. Currently, there is no vaccine to prevent infection with LD in humans, rather, prevention of this disease relies on avoiding exposure to the tick ... -
Development of Adenovirus-vectored Prototype Vaccines for African Swine Fever Virus and Bovine Viral Diarrhea Virus
Lokhandwala, Shehnaz Taher (2017-02-17)The objective of this work was to develop adenovirus-vectored prototype vaccines against two pathogens, African Swine Fever Virus (ASFV) and Bovine Viral Diarrhea Virus (BVDV), which cause disease in two major livestock ... -
The effect of bovine viral diarrhea virus (BVDV) strains on bovine monocyte-derived dendritic cells (Mo-DC) phenotype and capacity to produce BVDV
Rajput, Mrigendra KS; Darweesh, Mahmoud F; Park, Kaci; Braun, Lyle J; Mwangi, Waithaka; Young, Alan J; Chase, Christopher CL (Virology Journal, 2014) -
Enhancement of Innate Immunity to Control Viral Infections in Livestock Species
Ramirez Carvajal, Lisbeth (2014-07-08)During viral infection, host cell elicits the innate immune response by sensing pathogen associated molecular patterns (PAMPs) and triggering pathways that usually converge in the activation of interferon (IFN) and interferon ... -
Evaluating Immunogenicity of African Swine Fever Virus 9GL and 151R Antigens
Deblois, Kimberley Michelle (2013-02-04)Swine and wild boars in Africa, and parts of Europe and Russia continue being decimated by a severe form of hemorrhagic fever known as African Swine Fever (ASF). This viral disease has been responsible for the deaths of ... -
Evaluation of Arginine and Glutamine as Dietary Supplements to Enhance Edwardsiella ictaluri Vaccine Effectivness in Channel Catfish
Pohlenz Castillo, Camilo (2012-02-14)Rapid expansion of the aquaculture industry in recent decades has resulted in infectious diseases emerging as a major constraint to fish production, causing large economical losses worldwide. Therefore, prevention practices ... -
Evaluation of microencapsulation as an improved vaccination strategy against brucellosis
Arenas Gamboa, Angela Maria (2009-05-15)Brucellosis is an important zoonotic disease of nearly worldwide distribution. Despite the availability of live vaccine strains for bovine (S19, RB51) and small ruminants (Rev 1), these vaccines have several drawbacks ... -
Expression and Evaluation of Recombinant Babesia bovis Antigens of Vaccine Potential Against Tick Fever in Cattle
Lin, Huaiying 1986- (2013-01-07)Babesia bovis is a causative agent of bovine babesiosis and is transmitted by vector ticks, Rhipicephalus (Boophilus) spp. The disease has a high mortality rate in susceptible cattle, causing serious economic loss. At ... -
Identification and Evaluation of Brucella Recombinant Outer Membrane Proteins as Subunit Vaccinogen Candidates in the Mouse Model of Brucellosis
Gomez, Gabriel (2013-02-26)Despite being amongst the most common zoonotic diseases in the world, brucellosis is a neglected disease for which an approved vaccine for human use does not exist. Thus far, the traditional approaches to Brucella antigen ... -
Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease
Small, Christina M.; Ajithdoss, Dharani K.; Hoffmann, Aline Rodrigues; Mwangi, Waithaka; Esteve-Gassent, Maria D. (PLOS ONE, 2014-02-05)Lyme disease is the most prevalent arthropod borne disease in the US and it is caused by the bacterial spirochete Borrelia burgdorferi (Bb), which is acquired through the bite of an infected Ixodes tick. Vaccine development ... -
Immunogenic and Invasive Properties of Brucella melitensis 16M Outer Membrane Protein Vaccine Candidates Identified via a Reverse Vaccinology Approach
Gomez, Gabriel; Pei, Jianwu; Mwangi, Waithaka; Adams, L. Garry; Rice-Ficht, Allison; Ficht, Thomas A.; Bansal, Geetha P. (PloS One, 2013) -
Immunogenicity and Effects on Fecal Microbiome of an Electron-Beam Inactivated Rhodococcus equi Vaccine in Neonatal Foals
Bordin, Angela Ilha (2014-05-03)Rhodococcus equi is a bacterium commonly isolated from soil that primarily causes pneumonia in foals and immunocompromised adult horses. Many vaccines were designed and tested to protect foals from developing pneumonia; ... -
Immunogenicity of an Electron Beam Inactivated Rhodococcus equi Vaccine in Neonatal Foals
Bordin, Angela I.; Pillai, Suresh D.; Brake, Courtney; Bagley, Kaytee B.; Bourquin, Jessica R.; Coleman, Michelle; Oliveira, Fabiano N.; Mwangi, Waithaka; McMurray, David N.; Love, Charles C.; Felippe, Maria Julia B.; Cohen, Noah D.; Roop, Roy Martin (PloS One, 2014) -
Induction of Robust Immune Responses in Swine by Using a Cocktail of Adenovirus-Vectored African Swine Fever Virus Antigens
Lokhandwala, Shehnaz; Waghela, Suryakant; Bray, Jocelyn; Martin, Cameron; Sangewar, Neha; Charendoff, Chloe; Shetti, Rashmi; Ashley, Clay; Chen, Chang-Hsin; Berghman, Luc; Mwangi, Duncan; Dominowski, Paul; Foss, Dennis; Rai, Sharath; Vora, Shaunak; Gabbert, Lindsay; Burrage, Thomas; Brake, David; Neilan, John; Mwangi, Waithaka (Clinical and Vaccine Immunology - CVI, 2016)