Browsing by Author "Lin, Xiaorong"

Adaptation to Environmental Stresses in Candida glabrata

Huang, Mian (2017-05-10)

Candida glabrata (C. glabrata) is an emerging opportunistic human fungal pathogen with an increasing incidence as the cause of both mucosal and systemic infections. In addition, the fungus is the most commonly used ...

Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis

Zhai, Bing (2014-08-01)

Cryptococcosis is one of the leading causes of the deaths among AIDS patients. The high mortality rates of cryptococcosis are mainly due to inadequate information of its major causative agent Cryptococcus neoformans and ...

Aspergillus nidulans swoQ Plays an Important Role in Polarized Hyphal Growth

Bomer, Brigitte (2016-12-06)

Filamentous fungi form polarized hyphae by concentrating the addition of new material at the apex of the cell. The mechanics of polarized hyphal growth are coordinated by the cytoskeleton which utilizes microtubules (MTs) ...

Assessing conserved function of conidiation regulators in two distantly related ascomycetes, Aspergillus nidulans and Neurospora crassa

Chung, Da Woon (2012-07-16)

Conidiation is a common and critical asexual reproductive mode in fungi. The ascomycetes, the largest group in the kingdom Fungi undergo conidiation. The wide array of morphological difference in a conidiophore and conidial ...

Assessing the Roles of Striatin Orthologs in Fungal Morphogenesis, Sexual Development and Pathogenicity

Wang, Chih-Li (2012-10-19)

Striatin family proteins contain a caveolin binding domain, a coiled-coil motif, a calmodulin binding domain, and a WD-repeat domain. Homologs of striatin protein have been However, our knowledge of the function and the ...

Characterization of Caenorhabditis elegans as a Mycobacterium marinum Virulence Model

Galbadage, Don Thushara Nuwan (2017-02-16)

Mycobacterium marinum is a medically important aquatic pathogen that causes cutaneous granulomatous lesions in humans and a chronic tuberculosis-like granulomatous disease in ectotherms. M. marinum is commonly used as a ...

Conidiation Color Mutants of Aspergillus fumigatus Are Highly Pathogenic to the Heterologous Insect Host Galleria mellonella

Jackson, Jennifer C.; Higgins, Laura A.; Lin, Xiaorong; Mylonakis, Eleftherios (PloS One, 2009)

Development of Protective Inflammation and Cell-Mediated Immunity against Cryptococcus neoformans after Exposure to Hyphal Mutants

Zhai, Bing; Wozniak, Karen; Masso-Silva, Jorge; Upadhyay, Srijana; Hole, Camaron; Rivera, Amariliz; Wormley, Floyd; Jr.; Lin, Xiaorong (MBio, 2015)

A Family of Secretory Proteins Is Associated with Different Morphotypes in Cryptococcus neoformans

Gyawali, Rachana; Upadhyay, Srijana; Way, Joshua; Lin, Xiaorong (Applied and Environmental Microbiology, 2017)

Functional Analysis of Host Factors that Mediate the Intracellular Lifestyle of Cryptococcus neoformans

Qin, Qing-Ming; Luo, Jijing; Lin, Xiaorong; Pei, Jianwu; Li, Lei; Ficht, Thomas A.; de Figueiredo, Paul; Andrianopoulos, Alex (PLoS Pathogens, 2011)

Fungal adhesion protein guides community behaviors and autoinduction in a paracrine manner

Wang, Linqi; Tian, Xiuyun; Gyawali, Rachana; Lin, Xiaorong (Proceedings of the National Academy of Sciences of the United States of America, 2013)

In Vitro Evolutionary Dynamics of C. albicans during Adaptation to Fluocnazole

Huang, Mian (2012-10-19)

Many drug-resistant mechanisms in Candida albicans (C. albicans), a clinical important fungal pathogen, have been well characterized. However, few studies investigated the emergence of drug resistance from the evolutionary ...

Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation

Upadhyay, Srijana; Xu, Xinping; Lin, Xiaorong (MBio, 2016)

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

Wang, Linqi; Zhai, Bing; Lin, Xiaorong; May, Robin Charles (PLoS Pathogens, 2012)

Linking Fibrosis and Cancer through the Differentiation of Fibrocytes

White, Michael (2015-06-03)

Fibrosis is a disease in which scar tissue invades healthy organs and reduces their function. Fibrosis is involved in 45% of deaths in the United States, yet little is known about the signaling that underlies the early ...

The lncRNA RZE1 Controls Cryptococcal Morphological Transition

Chacko, Nadia; Zhao, Youbao; Yang, Ence; Wang, Linqi; Cai, James J.; Lin, Xiaorong; Butler, Geraldine (PLoS Genetics, 2015)

Molecular Characterization of MADS-BOX Transcription Factors and Analysis of Field Population Diversity in the Maize Pathogen Fusarium verticillioides

Ortiz, Carlos S (2013-04-10)

Fusarium verticillioides (Teleomorph Giberella moniliformis) is an ascomycete fungus responsible for ear and stalk rots of maize. Most importantly, it produces a group of mycotoxins called fumonisins upon colonization of ...