Endothelial cell (EC) junctions are critical for angiogenesis, the sprouting and growth of new blood vessels from existing vessels. Sphingosine 1-phosphate (S1P) is a proangiogenic factor that potently stimulates sprouting, ...

Extracellular matrix (hMatrix) derived from osteogenically enhanced mesenchymal stem cells (OEhMSCs) can be deposited onto scaffolds in a process referred to as “bioconditioning”. While bioconditioned gelatin scaffolds ...

Extracellular microenvironment, including its components and biophysical parameters such as matrix structure and stiffness, is a crucial determinant of cellular function. There exists interdependency between cellular ...

Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress due to the lack of suitable ...

Two-dimensional (2D) nanomaterials are an emerging class of biomaterials that have garnered unprecedented attention due to their unique atomically thin, layered, and well-defined structure. These nanomaterials, however, ...

Extracellular matrix (ECM) is a primary component of the osteogenic microenvironment, providing support for attachment, proliferation, and differentiation to facilitate bone growth and maintenance. Previously we have shown ...

Three-dimensional (3D) bioprinting is emerging as a promising method for rapid fabrication of biomimetic cell-laden constructs for tissue engineering using cell-containing hydrogels, called bioinks, that can be cross-linked ...

Osteoporosis-induced bone fractures affect approximately 2.6 million people in the United States, with over US$ 19 billion in related healthcare expenditures. Most of these patients live with this chronic condition, but ...

Tissue engineering (TE) approaches have emerged as an alternative to traditional tissue and organ replacements. The aim of this work was to contribute to the understanding of the effects of cell-material and endothelial ...