Browsing by Author "Fluckey, James D"

Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance

Galvan, Elfego (2015-10-05)

Creatine monohydrate (CrM) and nitrate are popular supplements for improving exercise performance; yet they have not been investigated in combination. We performed two studies to determine the safety and exercise ...

An Examination of a Novel Weight Loss Formula on Anthropometry and Indices of Cardiovascular Disease Risk

Sowinski, Ryan Joseph (2019-11-12)

Studies from Africa report supplementation with Dichrostachys glomerata (DG; 200–400 mg/d) has led to significant reductions in weight and fat in obese individuals, without exercise or diet intervention. The purpose of ...

Association Between Genetic Background and the Response to Exercise Training

Avila, Joshua J (2016-10-24)

Cardiorespiratory fitness has been shown to increase with physical activity regardless of intrinsic exercise capacity, age, sex, and race. However, the variation in the response to training is heterogeneous, including ...

Characterizing the Role of DEPTOR in the mTOR Pathway in Cellular Protein Homeostasis

Anjorin, Christopher I

Understanding the dynamic balance between protein synthesis and degradation is critical in characterizing skeletal muscle growth, maintenance, or wasting. Over 160,000 people in the United States suffer from Cachexia, a ...

Chemotherapeutic Myokines from Contracting Skeletal Muscle and Their Effects on Breast Cancer

Davis, Amanda Renee (2017-01-23)

Exercise has been shown to elicit beneficial effects in both the treatment and prevention of cancer, yet the biology potentiating the effects remains ambiguous. The hypothesis for this dissertation was that effluent perfusion ...

Concurrent Exercise and the Potential Role of Aquatic Treadmill Running for Promoting Rather than Impeding Skeletal Muscle Growth and Strength Development

Lambert, Bradley Stewart (2014-06-02)

The preservation of skeletal muscle mass, strength, and aerobic capacity have been demonstrated to be essential for maintaining one’s health, preventing a wide range of cardio-metabolic diseases, and improving quality of ...

Dietary Cholesterol and Resistance Training as Countermeasures to Accelerated Muscle Loss

Lee, Teak Veng (2015-12-09)

Cholesterol plays an important role in physiology, serving as a membrane constituent and steroid hormone precursor. Recently, cholesterol has also been associated with skeletal muscle homeostasis, leading to the purpose ...

Dietary Lipids, Lipid Regulation, and Resistance Exercise Responses

Chen, Chun Wen (2017-07-18)

Being the largest tissue that accounts for 40-50% of overall metabolism in non-obese individuals, skeletal muscle is a modifiable target for reducing the risk of chronic diseases. Resistance exercise induces cell signaling ...

Effects of Consuming a Food Bar Containing Whey Protein and Isomalto-Oliosaccharides on Glucose Homeostasis, Exercise Performance and Recovery

Grubic, Tyler Joseph (2018-11-06)

The pharmacokinetic study examined the glucose and insulinemic responses of ingesting a novel protein bar using plant fiber (isomalto-oligosaccharides, IMO). The purpose of the study was to determine the glycemic index ...

Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes

Dobson, Justin P (2015-01-26)

Dietary docosahexaenoic acid (DHA) (22:6 n-3) has been linked to many health benefits in sedentary populations, positively altering lipid profiles and reducing inflammation. The prospective impacts of DHA supplementation ...

Endocrine Disruptors and the Regulation of Voluntary Physical Activity in Mice

Schmitt, Emily Elizabeth (2015-05-12)

Physical inactivity is the underlying cause of a large variety of chronic health conditions, is the second leading actual cause of death in the United States, and is a major contributor to obesity and diabetes. In spite ...

Evaluation of Cell Culture Exercise Protocols using a Mechanical Stretch System for Analysis of DEPTOR Expression

Wudeck, Elyse Victoria (2013-02-04)

The generation and maintenance of muscle mass is a subject of interest across many scientific fields, including cancer, diabetes, and exercise physiology. Protein synthesis is a key step in the development and maintenance ...

Genetic Regulation of Intrinsic Endurance Exercise Capacity in Mice

Courtney, Sean M. (2013-07-26)

Endurance exercise capacity is a powerful predictor of health status. Having low levels of endurance exercise capacity has been linked with cardiovascular disease. Variation in endurance exercise capacity, measured during ...

Harvest and Isolate Skeletal Muscle Satellite Cells from Mice

Nguyen, Branden

Skeletal muscle tissue exhibits many plastic properties, changing its size or function in response to a variety of stressors. This adaptability is due, in part, to satellite cells, a type of multipotent adult stem cell ...

Inflammatory Bowel Disease and Bone: Mechanisms and Interventions for Inflammation-Induced Bone Alterations

Metzger, Corinne Elizabeth (2018-02-07)

Inflammatory bowel disease (IBD) effects approximately 1.6 million people in the United States with the incidence and prevalence increasing worldwide. All current treatments for IBD aim to simply mitigate the disease ...

Integration of Total Daily Protein Intake and Timing of Protein Supplementation on Muscle Anabolism during Simulated Elite Athlete Training in Fit Young Males

Simmons, Erin Elizabeth (2018-08-15)

A great deal of variation exists in recommendations of total daily protein intake and timing of supplementation for athletes. The most widely accepted recommendations promote protein intakes for strength and power ...