Smoothing splines provide flexible nonparametric regression estimators. Penalized likelihood method is adopted when responses are from exponential families and multivariate models are constructed with certain analysis of ...

Most bacterial foodborne pathogens are shed intermittently from their animal hosts and are able to grow and persist in the environment. Cattle and pigs constitute the major animal reservoirs for these pathogens. The overall ...

Exposure variables are often misclassified in observational studies. Any analysis that does not make proper adjustments for misclassification may result in biased estimates of model parameters and that may lead to distorted ...

This work presents three analyses of the NIH-AARP Study of Diet and Health. Each analysis develops recommendations for nutritional intake or physical behaviors, or alters existing recommendations. New statistical methodology ...

As a cost-efficient alternative to cohort design, case-control design is widely used in epidemiological studies. The primary analysis of the case-control studies focuses on the relationship between disease status and the ...

This dissertation focuses on methodology to integrate multiplatform genomic data with cancer applications. Such integration facilitates the discovery of biological information crucial to the development of targeted treatments. ...

We propose novel methods to tackle two problems: the misspecified model with measurement error and high-dimensional binary classification, both have a crucial impact on applications in public health. The first problem ...