Browsing by Author "Miranda, Rajesh"
Now showing items 21-40 of 44
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Liu, Jing (2009-05-15)Polymer-supported synthesis of a close analog (i.e. A) of an early lead, a 14- membered ring peptidomimetic D3, was described. The monovalent molecule was attached to different length linkers, and they were then paired ...
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Dave, Jui Mayank (2014-12-12)Angiogenesis is defined as growth of new blood vessels from pre-existing ones and occurs during normal physiological development as well as pathological conditions like cancer. During angiogenesis, normally quiescent ...
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Strickland, Eric (2013-05-30)Spinal cord injury (SCI) results in a number of devastating consequences, including loss of motor function, paralysis, and neuropathic pain. Concomitant peripheral tissue injury below the lesion site can result in ...
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Shende, Vikram Ravindra 1982- (2012-11-15)The circadian system in mammals is arranged as a hierarchical network of oscillators, with the master pacemaker of circadian rhythms located in the suprachiasmatic nuclei (SCN) of the hypothalamus and peripheral oscillators ...
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Tsai, Pai Chi (2014-05-05)Maternal alcohol consumption during pregnancy, especially during the first and second trimester, can cause the wide range of severe birth defects classified as fetal alcohol spectrum disorder (FASD). FASD is a wide spectrum ...
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Shah, Manasvi Shailesh 1984- (2012-12-05)We have hypothesized that dietary modulation of intestinal miRNA expression may contribute to the chemoprotective effects of nutritional bioactives (fish oil and pectin). Using a rat colon carcinogen model, we determined ...
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Branyan, Taylor E. (2023-06-22)Stroke is a leading cause of death and long-term disability in the United States. Women over the age of 55 have a higher lifetime risk of stroke and worse outcomes after stroke compared to men of the same age[1]. However, ...
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Aceves, Miriam (2017-05-02)Opioids are amongst the most effective and widely prescribed medications for the treatment of pain following spinal cord injury (SCI). Spinally-injured patients receive opioids shortly upon arrival at the emergency room, ...
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Paez, Ximena (2014-06-02)Spinal muscular atrophy (SMA) results from α-motor neuron loss in the spinal cord due to low levels of the survival of motor neuron (SMN) protein, required for proper spliceosome assembly. The reduced levels of SMN cause ...
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Puga, Denise Alejandra (2009-05-15)A substantial body of work exists to suggest that brain and spinal mechanisms react differently to nociceptive information. The current experiments were design to identify parallels and differences in the way the spinal ...
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Ramlachan, Nicole (Texas A&M University, 2006-04-12)The major histocompatibility complex (MHC) is a genomic region containing genes of immunomodulatory importance. MHC class I genes encode cell-surface glycoproteins that present peptides to circulating T cells, playing a ...
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Puga, Denise Alejandra (2012-07-16)We utilize a simple instrumental (response-outcome) learning task to measure spinal plasticity in the isolated spinal cord. Peripheral uncontrollable nociceptive input has been shown to disrupt spinal instrumental learning ...
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Bedi, Yudhishtar (2021-11-08)This dissertation examines the effect of paternal alcohol consumption on fetal growth and on the sperm epigenetic and noncoding RNA profile. Earlier studies have found links between paternal preconception alcohol consumption ...
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Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure Balaraman, Sridevi; Schafer, Jordan; Tseng, Alexander; Wertelecki, Wladimir; Yevtushok, Lyubov; Zymak-Zakutnya, Natalya; Chambers, Christina; Miranda, Rajesh (PloS One, 2016)
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Chronister, Sarah Katherine (2016-08-09)Epidemiologic studies demonstrate that alcohol is the most prevalent teratogen to which humans are exposed. In the US, it is estimated that at least one percent of children suffer from fetal alcohol spectrum disorder (FASD) ...
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Hsiao, Hao-Ching (2015-03-17)The objectives of this work include: validation of yeast-based assays, investigation of protein-protein interactions in the regulatory role of an intrinsically disordered protein, Ultrabithorax (Ubx), and exploration of ...
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Chung, Dae (2022-12-05)Prenatal alcohol/ethanol exposure (PAE) can result in Fetal Alcohol Spectrum Disorders (FASD), the leading cause of intellectual disability and growth deficits, and have immediate and lifelong adverse effects on an ...
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Maldonado, Sioui (2014-08-26)Spinal cord injury (SCI) leads to increased anxiety and depression in as many as 60% of patients. Yet despite extensive clinical research focused on understanding the variables influencing psychological well-being following ...
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The Relationship Between Blood Pressure, Locomotor Performance, and Hemorrhage After Noxious Input Malamakal, Misty Marie (2017-08-16)Pain input after a spinal cord injury (SCI) has been shown to be detrimental to recovery. Animal models show that noxious input soon after injury leads to an increase in hemorrhage three hours after stimulation and long-term ...
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Iftikhar, Hina (2018-11-23)Drosophila melanogaster courtship, although stereotypical, continually changes based on cues received from the courtship subject. Such adaptive responses are mediated via rapid and widespread transcriptomic reprogramming, ...