Browsing by Author "Majeti, Naga Venkata Ravi Kumar"

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    Polymer systems and their applications in diagnostics and drug delivery
    (United States. Patent and Trademark Office, 2020-09-22T00:00:00Z) Majeti, Naga Venkata Ravi Kumar; Saini, Prabhjot; Ganugula, Raghu; Arora, Meenakshi; The Texas A&M University System
    The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds.
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    Polymer/copolymer nanoparticles conjugated to gambogic acid
    (United States. Patent and Trademark Office, 2020-09-29T00:00:00Z) Majeti, Naga Venkata Ravi Kumar; Ganugula, Raghu; Arora, Meenakshi; Saini, Prabhjot; The Texas A&M University System
    A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH.sub.2Cl.sub.2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH.sub.2Cl.sub.2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH.sub.2Cl.sub.2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.