Randomized and Deterministic Parameterized Algorithms and Their Applications in Bioinformatics
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Parameterized NP-hard problems are NP-hard problems that are associated with special variables called parameters. One example of the problem is to find simple paths of length k in a graph, where the integer k is the parameter. We call this problem the p-path problem. The p-path problem is the parameterized version of the well-known NP-complete problem - the longest simple path problem. There are two main reasons why we study parameterized NP-hard problems. First, many application problems are naturally associated with certain parameters. Hence we need to solve these parameterized NP-hard problems. Second, if parameters take only small values, we can take advantage of these parameters to design very effective algorithms. If a parameterized NP-hard problem can be solved by an algorithm of running time in form of f(k)nO(1), where k is the parameter, f(k) is independent of n, and n is the input size of the problem instance, we say that this parameterized NP-hard problem is fixed parameter tractable (FPT). If a problem is FPT and the parameter takes only small values, the problem can be solved efficiently (it can be solved almost in polynomial time). In this dissertation, first, we introduce several techniques that can be used to design efficient algorithms for parameterized NP-hard problems. These techniques include branch and bound, divide and conquer, color coding and dynamic programming, iterative compression, iterative expansion and kernelization. Then we present our results about how to use these techniques to solve parameterized NP-hard problems, such as the p-path problem and the pd-feedback vertex set problem. Especially, we designed the first algorithm of running time in form of f(k)nO(1) for the pd-feedback vertex set problem. Thus solved an outstanding open problem, i.e. if the pd-feedback vertex set problem is FPT. Finally, we will introduce how to use parameterized algorithm techniques to solve the signaling pathway problem and the motif finding problem from bioinformatics.
SubjectAlgorithm, parameterized NP-hard problems, fixed parameter tractable, Directed feedback back vertex set problem, bioinformatics
Lu, Songjian (2009). Randomized and Deterministic Parameterized Algorithms and Their Applications in Bioinformatics. Doctoral dissertation, Texas A&M University. Available electronically from