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Importance of satellite cells in recovery from eccentric contraction-induced muscle injury
| dc.creator | Rathbone, Christopher Ronald | |
| dc.date.accessioned | 2012-06-07T23:21:12Z | |
| dc.date.available | 2012-06-07T23:21:12Z | |
| dc.date.created | 2003 | |
| dc.date.issued | 2003 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-2003-THESIS-R38 | |
| dc.description | Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. | en |
| dc.description | Includes bibliographical references (leaves 29-39). | en |
| dc.description | Issued also on microfiche from Lange Micrographics. | en |
| dc.description.abstract | The purpose of this study was to determine if the elimination of satellite cell proliferation with []-irradiation would inhibit normal force recovery following eccentric contraction-induced injury. Adult female ICR mice were implanted with a stimulating nerve cuff on the common peroneal nerve and assigned to one of four groups: 1) irradiation and eccentric contraction-induced injury, 2) eccentric contraction-induced injury only, 3) irradiation only, and 4) no intervention. Anterior crural muscles were irradiated with a dose of 2,500 rads and injured with 150 in vivo maximal eccentric contractions. Maximal isometric torque was determined weekly through 35 days after the induction of injury. Maximal isometric torque production by non-irradiated injured mice returned to normal by 28 days. However, torque production of irradiated injured animals did not recover, and was 16-25% less than injured non-irradiated mice 14-35 days post-injury. TA and EDL muscle wet weights of irradiated injured mice were 19 and 20% less than in non-irradiated injured mice, respectively. These data suggest satellite cell proliferation is required for normal force recovery following eccentric contraction-induced injury. | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.publisher | Texas A&M University | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.subject | kinesiology. | en |
| dc.subject | Major kinesiology. | en |
| dc.title | Importance of satellite cells in recovery from eccentric contraction-induced muscle injury | en |
| dc.type | Thesis | en |
| thesis.degree.discipline | kinesiology | en |
| thesis.degree.name | M.S. | en |
| thesis.degree.level | Masters | en |
| dc.type.genre | thesis | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
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