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dc.creatorLeGrange, Suzanne Naumanen_US
dc.date.accessioned2012-06-07T22:45:23Z
dc.date.available2012-06-07T22:45:23Z
dc.date.created1996en_US
dc.date.issued1996
dc.identifier.urihttp://hdl.handle.net/1969.1/ETD-TAMU-1996-THESIS-L45en_US
dc.descriptionDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionIssued also on microfiche from Lange Micrographics.en_US
dc.description.abstractThe purpose of this study was to determine the disposition of cisapride in cats following oral (PO) and intravenous (IV) administration of a single dose and the bioavailability (F) of the drug when administered as an oral capsule. 7 cats each were treated with either 1 mg/kg (IV) or 2 mg/kg (PO) after a 24 hour fast. Blood samples were collected intermittently for 36 hours following administration. Cats were studied in pairs using a random crossover design in which a cat receiving an oral dose was paired with one receiving an intravenous dose. Cisapride was detected with an HPLC assay validated for cat plasma. Drug concentration versus time curves were subjected to standard pharmacokinetic analysis. Disposition parameters were compared between PO and IV groups. Following IV administration, extrapolated peak cisapride concentration, Co, was 421.30 + 155.37 ng/ml; clearance was 0.015 + 0.0067 ml/min*kg; mean residence time (MRT) was 6.36 + 4.21 hr; and volume of distribution (Vdss) was 4.50 + 1.36 ml/kg. Cmax for the oral capsule was 73.32 + 16.59 ng/ml, MRT was 8.32 + 4.47 hr, and F was 29.0 + 22.6%. Elimination half-life was similar for both the oral and intravenous routes (T1/2(lv) = 5.19 + 3.77 hr, Tk(po) = 5.27 -+ 3.16 hr) . All cats tolerated all doses with no apparent adverse effects. Based on these data an oral dose of 1 mg/kg given every 8 hours should maintain an average concentration at steady state that lies within the published therapeutic range for people.en_US
dc.format.mediumelectronicen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherTexas A&M Universityen_US
dc.rightsThis thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use.en_US
dc.subjectveterinary medicine and surgery.en_US
dc.subjectMajor veterinary medicine and surgery.en_US
dc.titlePharmacokinetics of cisapride in normal healthy cats and recommended oral dosing regimenen_US
dc.typeThesisen_US
thesis.degree.disciplineveterinary medicine and surgeryen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelMastersen_US
dc.type.genrethesis
dc.type.materialtexten_US
dc.format.digitalOriginreformatted digitalen_US


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