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dc.contributor.advisorBurgess, Kevinen_US
dc.creatorLam, Sang Q.en_US
dc.date.accessioned2007-04-25T20:09:20Z
dc.date.available2007-04-25T20:09:20Z
dc.date.created2005-12en_US
dc.date.issued2007-04-25
dc.identifier.urihttp://hdl.handle.net/1969.1/4825
dc.description.abstractIn an effort to partially mimic the complex interaction between nerve growth factor (NGF) and its membrane-bound tyrosine kinase A receptor (TrkA), several small organic molecules with functionalities similar to the side-chains of the amino acid residues of NGF critical to binding were devised. These molecules were studied computationally using the program Affinity. Each molecule was individually docked onto one of the binding sites on TrkA as determined by mutagenesis studies and the x-ray crystal structure obtained from the Protein Data Bank. One of the strategies to enhance binding of active peptidomimetics to their target proteins is to link them together to form either homodimers or heterodimers. However, these dimers have low solubility in water and mimic only residues that are close together on the protein. Triethylene oxide- and hexaethylene oxide-based linker molecules were designed to circumvent these limitations. The increased polarity will improve the watersolubility and the added lengths, which can be controlled and varied by simple chemical manipulations, will allow for mimicking critical residues that are farther apart on the protein.en_US
dc.format.extent1838020 bytes
dc.format.mediumelectronicen_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherTexas A&M Universityen_US
dc.subjectpeptidomimeticsen_US
dc.subjectlinkersen_US
dc.subjectcomputationalen_US
dc.titleContributions to peptidomimetic design: predictive computational studies and syntheses of linker moleculesen_US
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorTexas A&M Universityen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelMastersen_US
dc.contributor.committeeMemberMiller, Stephen A.en_US
dc.contributor.committeeMemberTsai, Jerryen_US
dc.type.genreElectronic Thesisen_US
dc.type.materialtexten_US
dc.format.digitalOriginborn digitalen_US


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