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N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes
dc.contributor.advisor | Darensbourg, Marcetta Y. | |
dc.creator | Chiang, Chao-Yi | |
dc.date.accessioned | 2006-08-16T19:09:21Z | |
dc.date.available | 2006-08-16T19:09:21Z | |
dc.date.created | 2003-05 | |
dc.date.issued | 2006-08-16 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/3920 | |
dc.description.abstract | Nitric oxide plays an important role in many biological functions. A metallo derivative in biological systems is a protein-bound dinitrosyl iron complex (DNIC), which results from iron-sulfur cluster degradation in the presence of excess NO. Through model complexes I have examined the fundamental properties of a dithiolato-Fe(NO)2 complex, bismercaptoethandiazacyclooctane iron dinitrosyl or (H+bme-daco)Fe(NO)2 as a biomimic of dicysteinate coordination of [Fe(NO)2]. This complex was prepared and fully characterized in my studies. The DNIC moiety is in its oxidized state, {Fe(NO)2}9. Through reaction studies, monitored by IR spectroscopy (H+N2S2)Fe(NO)2 (N2S2 = bme-dach. Bme-pda) has been shown to transfer NO to FeIII in (TPP)FeCl (TPP = meso-tetraphenylporphyrin) as NO-. The remaining mononitrosyl converts into complex (N2S2)Fe(NO). The (N2S2)Fe(NO) complexes (N2S2 = bme-daco, bme*-daco, bme-dach) were prepared by direct reaction of dimeric [(N2S2)Fe]2 and NO gas. The analogous (N2S2)Co(NO) complex (N2S2 = bme-dach) has also been prepared. The series of square pyramidal (N2S2)M(NO) have been studied by cyclic voltammetry and ν(NO) IR spectroscopy. | en |
dc.format.extent | 3713762 bytes | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.publisher | Texas A&M University | |
dc.subject | N2S2 | en |
dc.subject | Fe(NO)2 | en |
dc.title | N2s2 chelating agents as cys-x-cys biomimics for fe(no) and fe(no)2 complexes | en |
dc.type | Book | en |
dc.type | Thesis | en |
thesis.degree.department | Chemistry | en |
thesis.degree.discipline | Chemistry | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Doctor of Philosophy | en |
thesis.degree.level | Doctoral | en |
dc.contributor.committeeMember | Gabbai, Francois P. | |
dc.contributor.committeeMember | Harris, Edward D. | |
dc.contributor.committeeMember | Hughbanks, Timothy R. | |
dc.type.genre | Electronic Dissertation | en |
dc.type.material | text | en |
dc.format.digitalOrigin | born digital | en |
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