Search
Now showing items 1-8 of 8
G Protein-coupled Estrogen receptor is activated by G-1 which induces a signaling cascade that inhibits breast cancer cell proliferation
(2012-06-08)
Breast cancer is the most common cancer in women and is predominantly estrogen dependent [1]. About 1 in 8 women in the United States (12%) will develop invasive breast cancer over the course of her lifetime. Failure in ...
Identification of Smooth Muscle Gamma Actin in Prostate Epithelia
(2013-09-25)
Prostate cancer is the second most common form of cancer in American men. Though broad treatments are available, these often have deleterious effects on the patient. One approach which may result in a more tailored treatment ...
Identification of PTEN Modifier Genes Using the Collaborative Cross Mouse Panel
Inactivation or mutation of phosphatase and tensin homolog (PTEN), a tumor suppressor gene, is implicated in unregulated cell proliferation, leading to tumor growth and the development of cancer. Identification of modifier ...
Design, Synthesis and Characterization of Peptide-guided Nanomaterial for Cancer Targeting
Specifically targeting cancer cells is much more efficient than non-targeted treatment because it decreases side effects and permits stronger treatment without as a risk of harming normal cells. Smart molecular probes and ...
CHALONE SIGNAL TRANSDUCTION PATHWAY IN DICTYOSTELIUM DISCOIDEUM: A POSSIBLE SIGNALING MECHANISM FOR CELL PROLIFERATION INHIBITION
(2014-10-14)
Cancer is a group of diseases characterized by uncontrolled cell proliferation. Cancer is responsible for nearly 1 of every 4 deaths, and ranks as the second highest cause of death worldwide, and costs the American population ...
GENETIC ANALYSYS OF THE IN VIVO FUNCTION AND REGULATION OF THE ONCOPROTEIN CDK8 IN DROSOPHILA
(2012-05-09)
Cyclin-Dependent Kinase 8 (CDK8) has recently emerged as an oncoprotein that is amplified in both colorectal and melanoma cancers. The importance of CDK8 and its regulatory partner Cyclin C (CycC) is highlighted by the ...
Characterizing Epithelial-Mesenchymal-Transition (EMT)-Like Behavior in Breast Cancer Cells in a Tissue Engineering Co-Culture Model
(2020-04-13)
Tissue engineered 3D cell culture models have shown promise investigating the influence of the tumor microenvironment on cancer cell behavior. Synthetic hydrogels, such as those made from poly(ethylene glycol) (PEG), can ...
Chemokine Mediated Regulation of Tumor-Lymphatic Crosstalk in Head and Neck Cancers
(2019-04-24)
A number of cancers disseminate first through the lymphatic system, and the presence of tumor cells in the sentinel or draining lymph node is a major prognostic indicator. Head and neck cancers (HNSCC) which preferentially ...