Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence
dc.contributor.advisor | Coté, Gerard | |
dc.creator | Wan, Qiujie | |
dc.date.accessioned | 2006-04-12T16:06:50Z | |
dc.date.available | 2006-04-12T16:06:50Z | |
dc.date.created | 2004-12 | |
dc.date.issued | 2006-04-12 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/3335 | |
dc.description.abstract | In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbits eyes. | en |
dc.format.extent | 900695 bytes | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.publisher | Texas A&M University | |
dc.subject | diabetes | en |
dc.subject | noninvasive | en |
dc.subject | polarimetry | en |
dc.subject | glucose sensing | en |
dc.subject | birefringence | en |
dc.title | Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence | en |
dc.type | Book | en |
dc.type | Thesis | en |
thesis.degree.department | Biomedical Engineering | en |
thesis.degree.discipline | Biomedical Engineering | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Master of Science | en |
thesis.degree.level | Masters | en |
dc.contributor.committeeMember | Taylor, Henry | |
dc.contributor.committeeMember | Wang, Lihong | |
dc.type.genre | Electronic Thesis | en |
dc.type.material | text | en |
dc.format.digitalOrigin | born digital | en |
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