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    Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence

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    etd-tamu-2004C-BMEN-Wan.pdf (879.5Kb)
    Date
    2006-04-12
    Author
    Wan, Qiujie
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    Abstract
    In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual wavelength system has been developed in order to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this paper a dual wavelength, closed-loop, system was designed and a model was developed to extract the glucose concentration information. The system and model were tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, non-moving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0-600mg/dl) for either laser wavelength (523nm or 635nm). In the presence of moving birefringence, each individual wavelength produced standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample. This research also shows promising preliminary results that the error is less than 25mg/dl in presence of a motion induced cornea birefringence artifact in NZW rabbitsÂ’ eyes.
    URI
    http://hdl.handle.net/1969.1/3335
    Subject
    diabetes
    noninvasive
    polarimetry
    glucose sensing
    birefringence
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    • Electronic Theses, Dissertations, and Records of Study (2002– )
    Citation
    Wan, Qiujie (2004). Dual wavelength polarimetry for monitoring glucose in the presence of varying birefringence. Master's thesis, Texas A&M University. Texas A&M University. Available electronically from http : / /hdl .handle .net /1969 .1 /3335.

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