Browsing Colleges and Schools by Author "Sacchettini, James C"
Now showing items 1-18 of 18
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Pham, Viet Truc (2019-01-14)Isocitrate lyase 1 & 2 are essential enzymes for Mycobacterium tuberculosis pathogenicity and antibiotic resistance, and thereby, are appealing targets for the treatment of latent tuberculosis. Since high-throughput screening ...
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Joseph, Sonia (2014-06-12)Tuberculosis is one of the leading causes of death due to infectious disease. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular parasite with a slow regeneration rate. Though there is a decline ...
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Salazar, Adam Janton (2019-02-12)This dissertation covers projects focused on the drug design and characterization of novel bacterial drug targets. The first project centers on acetolactate synthase (ALS), a key enzyme involved in the biosynthesis of ...
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Jeon, Junho (2013-10-16)A novel ion mobility-mass spectrometer was designed and built in order to achieve high transmission and high resolution for observing desolvated ion conformations of chemical and biological molecules in the gas phase. The ...
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Jung, Hunmin (2014-12-17)The goal of this study was to develop drugs that exclusively affect pathogenic dihydrofolate reductase (DHFR) without causing harm to the human counterpart. To achieve that goal, a well-known dihydrofolate reductase (DHFR) ...
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Crespo Morales, Roberto A (2017-12-05)The rapid emergence of drug-resistant Mycobacterium tuberculosis (Mtb) coupled to the high incidence of HIV-Mtb coinfection is of global concern. Consequently, there is a worldwide necessity to develop new drugs with novel ...
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Gulten, Gulcin (2014-03-18)Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is one of the leading infectious diseases worldwide. The current therapy for drug-sensitive TB is complex and lasts for at least six months. ...
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Guthrie, Liam M (2022-07-20)Copper is an essential micronutrient required for the proper biological function of numerous enzymes. Absorption, transportation, and elimination of copper is highly regulated due to potential pathological effects of copper ...
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Thapa, Hem R (2017-06-28)The colony-forming green microalga Botryococcus braunii is a potential source of biofuel feedstocks as it produces large amount of liquid hydrocarbon oils that can be converted into combustion engine fuels. There are three ...
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Van, Khoi Ngoc (2017-05-09)The developments of novel catalytic transformations are just as important as the discoveries of new reactions. In the most common way, catalysts provide more efficient and economical alternatives to known reactions. Arguably, ...
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De Jesus Aneiro, Michael A. (2016-12-02)Transposon Sequencing (TnSeq) has become a popular biological tool for assessing the phenotypes of large libraries of bacterial mutants at the same time. This allows for high-throughput identification of genes which are ...
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Huang, Hsiao-Ling (2016-02-12)As the world population battles drug-resistant tuberculosis (TB), there is an urgent need for novel anti-tubercular drugs. This dissertation documents the studies of glyoxylate shunt enzymes, isocitrate lyase (ICL) and ...
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Shetty, Nishant 1977- (2012-12-03)This dissertation uses two different approaches to the identification of inhibitors of Mycobacterium tuberculosis (Mtb) - a structure-based drug discovery approach and a high-throughput screening of natural product libraries ...
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Lalgondar, Mallikarjun (2014-03-21)Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate (3DHS) to shikimate (SKM) utilizing NADPH cofactor in the shikimate pathway, a central route for biosynthesis of aromatic ...
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Aggarwal, Anup (2014-04-01)Mycobacterium tuberculosis (Mtb) is a deadly pathogen that causes the infectious diseases Tuberculosis (TB) in humans. The emergence of drug resistant TB has created an urgent need for the development of new chemotherapeutics ...
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Tsai, Han-Chun (2013-08-09)Tuberculosis and malaria are among the most deadly infectious diseases in the world. The prevalence in regions without well-established public health causes economical and financial burdens for both society and patients. ...
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Ellenbarger, Jill Frank (2016-08-01)Supramolecular chemistry encompasses the interdisciplinary study of weak intermolecular forces which allows for access to sophisticated architectures and functionalities. One newly recognized supramolecular force that is ...
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Harshbarger, Wayne (2015-02-09)20S proteasomes are large, multicatalytic N- terminal threonine proteases which are tasked with maintaining intracellular homeostasis by the breaking down of mis-folded, oxidized, or tagged proteins into small peptides. ...