Browsing Colleges and Schools by Author "Pace, C. Nick"
Now showing items 1-20 of 20
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Schmittschmitt, Jason Peter (Texas A&M University, 2004-09-30)The HPr proteins were characterized as folding by a two-state folding mechanism. Here, we present a comparison of the equilibrium and kinetic folding for the HPr protein from Bacillus subtilis, E coli and a key variant ...
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Syed Ali, Abbas Razvi (Texas A&M University, 2006-04-12)A thermodynamic study of five homologous HPr proteins derived from organisms inhabiting diverse environments has been undertaken. The aim of this study was to further our understanding of protein stabilization in extremes ...
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Schell, David Andrew (Texas A&M University, 2005-02-17)Properly folded proteins are necessary for all living organisms. Incorrectly folded proteins can lead to a variety of diseases such as Alzheimers Disease or Bovine Spongiform Encephalitis (Mad Cow Disease). Understanding ...
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Wei, Yun (2010-07-14)Proteins need fold to perform their biological function. Thus, understanding how proteins fold could be the key to understanding life. In the first study, the stability and structure of several !-hairpin peptide variants ...
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Thurlkill, Richard Lee (Texas A&M University, 2007-04-25)A goal of the modern protein chemist is the design of novel proteins with specific activities or functions. One hurdle to overcome is the ability to accurately predict the pKas of ionizable groups upon their burial in the ...
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Wahlman, Judit (2009-05-15)Secretory proteins that are unable to assemble into native proteins in the endoplasmic reticulum (ER) are transported back into the cytosol for degradation. Many cytosolic and ER resident proteins have been identified so ...
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Trefethen, Jared M. (Texas A&M University, 2005-02-17)The primary objective was to study the kinetics of folding of RNase Sa. Wild-type RNase Sa does not contain tryptophan. A tryptophan was substituted at residue 81 (WT*) to allow fluorescence spectroscopy to be used to ...
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Presta, Leonard George (Texas A&M University. Libraries, 1985)Model complexes of porcine pancreatic elastase with the inhibitor, trifluoroacetyl-Lys-Ala-p-trifluoromethylanilide, and of bovine trypsin with the microbial inhibitor, leupeptin, were generated using interactive computer ...
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Pierce, Jennifer (Texas A&M University. Libraries, 1991)Transcription from the mouse mammary tumor virus (MMTV) promoter is regulated through the complex interaction of regulatory and promoter elements. Analysis of the promoter using a transient transfection assay has identified ...
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Miles, Jr., George Emmett (Texas A&M University, 2006-08-16)Staphylococcal leukocidin pores are formed by the obligatory interaction of two distinct polypeptides, one of class F and one of class S, making them unique in the family of β-barrel pore-forming toxins (β-PFTs). ...
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Norman, Eric Jesse (Texas A&M University. Libraries, 1977)Dipeptides were concerted to the N-acetyl-O-n-butyl derivatives and individual mass spectra were recorded. A library of more than 50 of these spectra were placed on magnetic tape. Dipeptide derivative mixtures were prepared ...
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Alston, Roy Willis (Texas A&M University, 2004-09-30)To understand protein stability and the mechanism of protein folding, it is essential that we gain a better understanding of the ensemble of conformations that make up the denatured state of a protein. The primary goal ...
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Waddle, Jenny Janine (Texas A&M University. Libraries, 1990)Bacterial luciferase from Vibrio harveyi is a heterodimeric enzyme comprised of two homologous subunits, α and β, encoded by adjacent genes, luxA and luxB. The level of accumulation of active enzyme was similar when the ...
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Rodriguez Rodriguez, Mauricio (Texas A&M University, 2006-10-30)This manuscript presents a thorough investigation and description of metabolic control dynamics in vivo and in silico using as a model de novo pyrimidine biosynthesis. Metabolic networks have been studied intensely for ...
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Chen, Lorenzo Harry (Texas A&M University. Libraries, 1989)Luciferase from the Vibrio harveyi mutant AK-20 contains a lesion in the α subunit that results in decreased bioluminescence activity relative to the wild type. In addition, the AK-20 luciferase exhibits altered activities ...
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Wood, Carla Mauree (Texas A&M University. Libraries, 1983)The mechanism by which insulin acts to inhibit intracellular protein degradation has been investigated in differentiating 3T3-L1 preadipocytes, Balb/c 3T3 fibroblasts, and SV40-transformed Balb/c 3T3 fibroblasts. Intracellular ...
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Zhang, Li (Texas A&M University, 2008-10-10)Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. Viral CC chemokine ...
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Tang, Hsiao-Yuan (Texas A&M University. Libraries, 1993)The 230 kD bullous pemphigoid antigen (BP230 or BPAG1) is a major protein of the cytoplasmic dense plaque of the epidermal hemidesmosome (HD) which may link keratin filaments to transmembrane proteins. The BP230 sequence ...
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Carson, Kenneth Harris (2009-06-02)Many proteins can easily attain a non-native fold and be of no use or even a detriment to the host. The host cell has a myriad of molecules dedicated to assisting nascent and existing proteins in folding properly and ...
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Denu, John Mattew (Texas A&M University. Libraries, 1993)The mechanism of hog kidney D-amino acid oxidase with glycine, D-alanine and D-serine as substrates has been examined in detail using the methods of pH effects and primary, secondary and solvent kinetic isotope effects. ...