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dc.contributor.advisorSulikowski, Gary A.en_US
dc.creatorQu, Taoen_US
dc.date.accessioned2005-11-01T15:50:44Z
dc.date.available2005-11-01T15:50:44Z
dc.date.created2004-08en_US
dc.date.issued2005-11-01
dc.identifier.urihttp://hdl.handle.net/1969.1/2738
dc.description.abstractMarine sponges produce a series of complex polycyclic diamine alkaloids which appear to have a common biogenesis from simple bis-pyridine macrocycles. These structurally novel secondary metabolites are presumably biosynthetically produced by the controlled ionic coupling of macrocyclic 3-alkyl piperidines leading to 3,4??-linked bis-piperidines (ii). Included among these diamine marine alkaloids is haliclonacyclamine C (i) which serves as our synthetic target. Chapter I in this thesis provides background information describing biological activity and proposed biosynthetic pathways to these important diamine marine alkaloids. Chapter II details progress towards the total synthesis of haliclonacyclamine C. The focus of Chapter II will be on our successful construction of the 3,4??-linked bispiperidine central core (ii) highlighted by the use of palladium-mediated C-C bond forming processes. The stereoselective hydrogenation of a coupled product will also be discussed.en_US
dc.format.extent809328 bytes
dc.format.mediumelectronicen_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherTexas A&M Universityen_US
dc.subjecttotal synthesisen_US
dc.subjectmarine alkaloidsen_US
dc.titleStudies towards the total synthesis of the macrocyclic diamine alkaloid haliclonacyclamine Cen_US
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorTexas A&M Universityen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelMastersen_US
dc.contributor.committeeMemberRomo, Danielen_US
dc.contributor.committeeMemberSingleton, Danielen_US
dc.contributor.committeeMemberWilliams, Howarden_US
dc.type.genreElectronic Thesisen_US
dc.type.materialtexten_US
dc.format.digitalOriginborn digitalen_US


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