Mineral-based nanoparticles for arthritis treatment
Abstract
Aspects of the invention are directed to mineral-based nanoparticles comprising silicate nanoparticles that induce human mesenchymal stem cells (hMSCs) into a cartilage-lineage through the upregulation of cartilage-specific genes resulting in the transformation of the cell phenotype into that of a chondrocyte, i.e., a cartilage producing cell. The silicate nanoparticles are synthesized through a process where the precipitate of sodium silicate is mixed with one or more elements and compounds and milled into nanoparticles.
Subject
A61K 35/28A61K 9/5115
A61K 35/32
C08K 3/34
A61K 9/0024
A61K 9/5161
C12N 5/0655
A61K 9/14
A61K 47/6923
B82Y 5/00
C12N 2533/10
C12N 2506/1353
C12N 2500/05
C08K 2201/011
B82Y 40/00
Collections
Citation
Gaharwar, Akhilesh K.; Carrow, James K. (2021). Mineral-based nanoparticles for arthritis treatment. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /193357.