In vivo live 3D printing of regenerative bone healing scaffolds for rapid fracture healing
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Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.
SubjectB33Y 70/00 (2014.12)
A61K 31/722 (2013.01)
A61K 33/00 (2013.01)
A61K 38/39 (2013.01)
Varanasi, Venu G.; Ilyas, Ashar; Kramer, Philip Roger; Azimaie, Taha; Aswath, Pranesh B.; Cebe, Tugba (10/1). In vivo live 3D printing of regenerative bone healing scaffolds for rapid fracture healing. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from