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dc.contributor.advisorNation, Jack R.en_US
dc.creatorValles, Rodrigo, Jr.en_US
dc.date.accessioned2004-09-30T01:45:07Z
dc.date.available2004-09-30T01:45:07Z
dc.date.created2003-08en_US
dc.date.issued2004-09-30
dc.identifier.urihttp://hdl.handle.net/1969.1/182
dc.description.abstractRationale: Lead-exposure during developmental periods may alter reinforcing patterns of drugs of abuse in adulthood. Anxiety related mechanisms may also influence drug intake. Interactions between the two altering factors may exist. Objectives: The present study examined the effects of perinatal lead-exposure on cocaine self-administration after a GABAA antagonist pre-treatment. Methods: Female rats were exposed to a regimen of 16 mg lead daily for 30 days prior to breeding with un-exposed males. This continued throughout gestation and lactation until postnatal day (PND) 21. On PND 63, animals were implanted with indwelling jugular catheters. After a 7 day recovery period, animals were trained to self-administer 0.50 mg/kg cocaine intravenously [IV]. After stable responding had been established, testing procedures began using combinations of 0.03 and 0.06 mg/kg cocaine [IV] and 0.00, 0.50, 1.00 and 2.00 mg/kg bicuculline (a GABAA antagonist) intraperitoneal [IP]. Results: Bicuculline pre-treatment caused directionally opposite effects in both treatment groups (Group 0-Lead and Group 16-Lead) at the 0.06 mg/kg cocaine dose. Group 0-Lead animals showed an increase in self-administration, while Group 16-Lead animals showed a decrease in responding on the active (cocaine) lever. Results at the 0.03 mg/kg cocaine dose showed no discernable pattern. Group 0-Lead animals decreased in active lever responding at the 2.00 mg/kg bicuculline dose. Group 16-Lead animals showed no differences in responding at any dose of bicuculline. Conclusions: These data further suggest the influential role of GABA in mediating cocaine reward and the ability of developmental lead-exposure to alter mechanisms mediating drug responsiveness even after exposure has terminated.en_US
dc.format.extent383762 bytes
dc.format.extent89138 bytes
dc.format.mediumelectronicen_US
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_USen_US
dc.publisherTexas A&M Universityen_US
dc.subjectPerinatalen_US
dc.subjectLeaden_US
dc.subjectCocaineen_US
dc.subjectGABAen_US
dc.subjectBicucullineen_US
dc.titleThe effects of bicuculline on cocaine self-administration in male rats developmentally exposed to leaden_US
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentPsychologyen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorTexas A&M Universityen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelMastersen_US
dc.contributor.committeeMemberBratton, Gerald R.en_US
dc.contributor.committeeMemberWellman, Paul J.en_US
dc.type.genreElectronic Thesisen_US
dc.type.materialtexten_US
dc.format.digitalOriginborn digitalen_US


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