Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands
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A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.
Monikis, Dmitrios; Floudas, Christodoulos; Woodruff, Trent; Cooper, Matthew A.; Croker, Daniel E.; Monk, Peter, N. (2019). Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from