Compositions and methods of enhancing immune responses to enteric pathogens
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Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
Bielke, Lisa; Layton, Sherryll; Hargis, Billy; Pumford, Neil R.; Faulkner, Olivia B.; Berghman, Luc; Abi-Ghanem, Daad (2019). Compositions and methods of enhancing immune responses to enteric pathogens. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from