Compositions and methods for drug sensitization of parasites
Abstract
Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof in an amount and formulation sufficient to inhibit or induce drug-sensitization in a parasite. The methods can comprise administering a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof to a parasite in an amount and formulation sufficient to inhibit or induce drug-sensitization in the parasite.
Subject
A61K 34/454A61K 31/427
A61K 31/435
A61K 31/5377
A61K 31/7048
A61K 45/06
A61K 47/542
A61K 47/545
Y02A 50/411
Y02A 50/414
Y02A 50/419
Y02A 50/421
Y02A 50/423
Y02A 50/491
A61P 33/00
A61K 31/454
A61K 2300/00
Y02A 50/49
Y02A 50/30
A61P 33/00
Collections
Citation
Sacchettini, James, C.; Miller, Matthew W.; Wallis, Deann; Zhou, Nian E.; Fossum, Theresa W. (2019). Compositions and methods for drug sensitization of parasites. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177806.