Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents
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Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
Raushel, Frank M.; Bigley, Andrew N. (2019). Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from