dc.creator | Cirillo, Jeffrey D. | |
dc.creator | Rao, Jianghong | |
dc.date.accessioned | 2019-06-17T17:11:43Z | |
dc.date.available | 2019-06-17T17:11:43Z | |
dc.date.issued | 2016-09-13 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/177169 | |
dc.description.abstract | Provided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 14/044825 | |
dc.date.filed | 2013-10-02 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | C12Q 1/34 | |
dc.subject.cpcprimary | A61K 49/0013 | |
dc.subject.cpcprimary | A61K 49/0021 | |
dc.subject.cpcprimary | A61K 49/0028 | |
dc.subject.cpcprimary | A61K 49/0032 | |
dc.subject.cpcprimary | A61K 49/0041 | |
dc.subject.cpcprimary | A61K 49/0052 | |
dc.subject.cpcprimary | C09B 57/02 | |
dc.subject.cpcprimary | C12Q 1/04 | |
dc.subject.cpcprimary | C12Q 1/66 | |
dc.subject.cpcprimary | G01N 2333/986 | |