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dc.creatorCirillo, Jeffrey D.
dc.creatorRao, Jianghong
dc.date.accessioned2019-06-17T17:11:43Z
dc.date.available2019-06-17T17:11:43Z
dc.date.issued2016-09-13
dc.identifier.urihttps://hdl.handle.net/1969.1/177169
dc.description.abstractProvided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product.en
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.titleUse of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeuticsen
dc.typeUtility patenten
dc.format.digitalOriginreformatted digitalen
dc.description.countryUS
dc.contributor.assigneeThe Texas A&M University System
dc.identifier.patentapplicationnumber14/044825
dc.date.filed2013-10-02
dc.publisher.digitalTexas A&M University. Libraries
dc.subject.cpcprimaryC12Q 1/34
dc.subject.cpcprimaryA61K 49/0013
dc.subject.cpcprimaryA61K 49/0021
dc.subject.cpcprimaryA61K 49/0028
dc.subject.cpcprimaryA61K 49/0032
dc.subject.cpcprimaryA61K 49/0041
dc.subject.cpcprimaryA61K 49/0052
dc.subject.cpcprimaryC09B 57/02
dc.subject.cpcprimaryC12Q 1/04
dc.subject.cpcprimaryC12Q 1/66
dc.subject.cpcprimaryG01N 2333/986


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