Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration
Abstract
The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the treatment of eye disease, particularly diseases of the retina. In particular aspects, the invention includes administration of a therapeutic polypeptide such as a stanniocalcin family member protein for the treatment of an eye disease. Also included are fusion proteins and cells stimulated or modified to express the therapeutic polypeptides as set forth herein.
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Citation
Rosa, Robert; Roddy, Gavin W.; Prockop, Darwin J. (2014). Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177070.