Sensor having piezoelectric crystal for microgravimetric immunoassays
Abstract
A sensor and method for performing immunoassays using surface acoustic waves on a piezoelectric crystal is provided. A specific antigen or antibody is bonded to the surface of the piezoelectric crystal and its resonant frequency in a blank solution is determined. The sensor is then exposed to a test solution containing an antigen or antibody corresponding to the substance bonded to the surface of the crystal. As the antigen and antibody react, the resonant frequency of the crystal is altered. This change can be correlated to determine the amount of antigen or antibody in the test solution. A nonreactive reference sensor can also be used to compensate for any nonselective adsorption.
Subject
436/527324/71.1
367/157
436/501
436/518
436/806
G01N 29/022
G01N 33/54373
Y10S 436/806
G01N 2291/0423
G01N 2291/0426
G01N 2291/0256
Collections
Citation
Bastiaans, Glenn J. (1988). Sensor having piezoelectric crystal for microgravimetric immunoassays. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176809.