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Investigating the response to Indole derivatives through the Aryl hydrocarbon receptor and Other Signaling Pathways
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Gastrointestinal tract bacteria can transform molecules into metabolites that can either be utilized by the mammalian host or can induce signaling in the host. One such metabolite, indole (and its derivatives), is generated from the amino acid tryptophan. Indole is small and can passively diffuse into the host cell. Indole and its derivatives such as indole-3-acetate (I3A) have been shown to activate the the aryl hydrocarbon receptor (Ahr), which, in turn, activates a range of signaling pathways. However, preliminary data from our lab suggest that indole derivatives also bind to extracellular cell surface receptors. This work proposes to investigate the balance between Ahr-mediated signaling and Ahr-independent signaling by indole derivatives. This project also seeks to develop a mathematical model to describe this mechanism, as well as test the general applicability of this response in different cell lines.
Fris, Eric Allen (2017). Investigating the response to Indole derivatives through the Aryl hydrocarbon receptor and Other Signaling Pathways. Undergraduate Research Scholars Program. Available electronically from