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Development of a Demineralized Dentin Matrix Hydrogel for Dental Pulp Regeneration
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Regenerative endodontics is one of the most exciting new developments in endodontics. Pulp regeneration can be achieved basically by using a triad of a reliable cell source capable of differentiating, a suitable scaffold, and signaling molecules that direct the cells for proliferation and cellular differentiation. Injectable scaffolds are favorable for regeneration of pulp-dentin complex as the surgery is minimally invasive, easy to place in small and irregular pulp canals, have a homogenous distribution, helps cell adhere, proliferate and differentiate into new functional tissue and reduces the risk of infection. We aim to develop a biomimetic injectable biomaterial that would facilitate pulp regeneration and have the potential for clinical application. We hypothesized that demineralized dentin matrix, which mainly consist of collagen and non- collagenous proteins, will provide a favorable microenvironment for pulp-dentin regeneration. Characteristics of demineralized dentin matrix hydrogel along with the in vitro experiments have been studied, which makes the assumptions clear that it mimics the extracellular matrix of the dentino-pulpal tissue and helps in maintaining the cellular viability along with cell proliferation and differentiation. In conclusion, we can say that the demineralized dentin matrix provides a suitable environment for the dental pulp stem cells to grow and differentiate in different lineages. More studies should be conducted for further characterization of the demineralized dentin matrix for translational use.
Ahuja, Neelam (2017). Development of a Demineralized Dentin Matrix Hydrogel for Dental Pulp Regeneration. Master's thesis, Texas A & M University. Available electronically from