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Effects of Exercise and Diet-Induced Weight Loss in Sedentary Obese Women on Inflammatory Markers, Resistin and Visfatin
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Resistin and visfatin are secreted by adipose tissue and are potential regulators of inflammation and insulin sensitivity. This study examined the effects of exercise and diet-induced weight loss on resistin and visfatin. Twenty six sedentary obese women were randomly assigned into control group (C) or an exercise plus diet group (DE) that involved circuit resistance-exercise (4 d/week) with walking (10,000 steps/d, 3 d/week) while consuming 1,200 kcal/day for 1 week and 1,500 kcal/d diet for 11 weeks consisting of 45:30 % Protein:Carbohydrate. Body composition and fasting blood samples were obtained and analyzed by MANOVA and Pearson correlation analysis. Data are presented as mean±SD changes from baseline. Participants in the DE group lost more weight (DE: -5.9±4.0; C: 0.64±1.4 kg, p<0.001) and fat (DE: -5.1±4.5; C: 0.4±1.5 kg, p=0.001). Significant differences were seen between groups in leptin (DE: -17.8±21.9; C: 4.5±16.0 ng/ml, p=0.003), IL-6 (DE: -1.9±4.2; C: 2.7±1.2 ng/ml, p=0.001) and TNF-α (DE: -.2±2.1; C: 1.7±1.5 ng/ml, p=0.013) while visfatin (DE: 0.85±14.9; C: 20.2±37.1 ng/ml, p=0.10) and insulin (DE: -8.5±15.0; C: 0.12±7.7 IU/ml, p=0.07) tended to differ between groups. No significant differences were seen in changes in resistin (DE: 18.6±100; C: 59.9±162.2 ng/ml, p=0.452) or glucose (DE: -3.8±19.8; C: -2.8±6.9 %, p=0.87). Significant correlations were seen between changes in IL-6 and resistin (r=0.430, p=0.028) and changes in resistin and visfatin (r=0.417, p=0.034). These findings indicate that exercise and diet-induced weight loss have an effect on resistin and visfatin.
Khanna, Deepesh (2016). Effects of Exercise and Diet-Induced Weight Loss in Sedentary Obese Women on Inflammatory Markers, Resistin and Visfatin. Doctoral dissertation, Texas A & M University. Available electronically from