Nonsteroidal Anti-Inflammatory Drug Treatment of Cockatiels (Nymphicus hollandicus) Experimentally Inoculated with Parrot Bornavirus 2
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This study investigated the effects of nonsteroidal anti-inflammatory drugs on cockatiels experimentally inoculated with Parrot bornavirus-2 (PaBV-2). Twenty-seven cockatiels were randomized into 3 groups of 9 birds each taking into consideration historical PaBV shedding, weight, and sex. Cockatiels were then inoculated with cell culture derived PaBV-2 by the intranasal and intramuscular routes. At 23 days post-inoculation, each group received either oral treatment once daily with celecoxib (10.0 mg/kg), meloxicam (1.0 mg/kg) or placebo. Within 33-79 days post-inoculation; 2 birds were found dead and 6 birds were euthanized based on neurological or gastrointestinal signs consistent with proventricular dilatation disease. At day 173±2 post-inoculation, the remaining birds (21) were euthanized. Necropsy and histopathology results showed lesions characteristic of proventricular dilatation disease in most of the cockatiels; there was no statistical difference in the nature or severity of lesions between the 3 treatment groups. There was no statistical difference between the 3 treatment groups in the detection of PaBV mRNA and PaBV N-protein using RT-PCR and immunohistochemistry, respectively. Two birds from the meloxicam and 2 birds from the celecoxib groups had black intestinal contents consistent with intestinal bleeding. These findings suggest that the use of meloxicam or celecoxib does not alter the clinical presentation, viral shedding, gross lesions, histopathology, or viral distribution in cockatiels experimentally inoculated with PaBV-2.
SubjectParrot bornavirus 2
Proventricular dilatation disease
Nonsteroidal anti-inflammatory drug
Escandon, Paulina (2015). Nonsteroidal Anti-Inflammatory Drug Treatment of Cockatiels (Nymphicus hollandicus) Experimentally Inoculated with Parrot Bornavirus 2. Master's thesis, Texas A & M University. Available electronically from