MiR-150, A Novel and Potent Regulator for MLL-AF9 Leukemic Stem Cells
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MicroRNAs (miRNAs) are a class of short, non-coding RNAs that post-transcriptionally regulate gene expression, particularly in cancers. MicroRNA-150 has been proven as a critical regulatory for normal hematopoiesis and a potent inhibitor of MLL-AF9 leukemias. To understand the potential mechanism of how miR-150 suppresses MLL-AF9 leukemia through the regulation of leukemic stem cells (LSCs), the gain- and loss-of miR-150 strategies were adopted on an established MLL-AF9 expressing cell line. Gain-of-function will be carried out with miR-150 overexpressing construct and loss-of-function of miR-150 will be performed by utilizing a newly established sponge system to achieve chromosomal recombination. The effect of miR-150 on MLL-AF9 LSCs will evaluated using multiple methodologies.
Cheruku, Patali (2013). MiR-150, A Novel and Potent Regulator for MLL-AF9 Leukemic Stem Cells. Honors and Undergraduate Research. Available electronically from