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dc.creatorDrost, Taylor
dc.date.accessioned2015-09-03T15:24:23Z
dc.date.available2015-09-03T15:24:23Z
dc.date.created2013-05
dc.date.issued2013-02-04
dc.date.submittedMay 2013
dc.identifier.urihttps://hdl.handle.net/1969.1/154870
dc.description.abstractWhen ticks feed, they inject numerous proteins into the host that modulate the host’s defense mechanism to tick feeding activity. When animals are repeatedly infested with ticks, they develop an immune response to tick saliva proteins. On these animals ticks have difficulties to complete feeding, acquire, and transmit disease agents, and reproduce. Thus immunization of animals with recombinant tick saliva proteins has been proposed. The strategy of this research is to deliver chimeric tick saliva protein antigens. Three cross-tick species conserved genes that encode for Lone Star tick, Amblyomma americanum tick saliva proteins were identified. cDNA regions that code for putative immunogenic regions were spliced together to make a chimeric tick saliva protein. The recombinant tick saliva protein chimera will be expressed and used to immunize rabbits against tick feeding.en
dc.format.mimetypeapplication/pdf
dc.subjectAmblyomma americanumen
dc.subjecttick vaccine developmenten
dc.subjecttick saliva proteinsen
dc.subjectprotein chimerasen
dc.titleDesigning and Expressing a Recombinant Tick Saliva Chimeraen
dc.typeThesisen
thesis.degree.departmentBiomedical Sciences Programen
thesis.degree.disciplineBiomedical Scienceen
thesis.degree.grantorHonors and Undergraduate Researchen
dc.contributor.committeeMemberMulenga, Albert
dc.type.materialtexten
dc.date.updated2015-09-03T15:24:23Z


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