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dc.creatorHe, Chong
dc.creatorTsuchiyama, Scott K.
dc.creatorNguyen, Quynh T.
dc.creatorPlyusnina, Ekaterina N.
dc.creatorTerrill, Samuel R.
dc.creatorSahibzada, Sarah
dc.creatorPatel, Bhumil
dc.creatorFaulkner, Alena R.
dc.creatorShaposhnikov, Mikhail V.
dc.creatorTian, Ruilin
dc.creatorTsuchiya, Mitsuhiro
dc.creatorKaeberlein, Matt
dc.creatorMoskalev, Alexey A.
dc.creatorKennedy, Brian K.
dc.creatorPolymenis, Michael
dc.identifier.citationHe C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, et al. (2014) Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import. PLoS Genet 10(12): e1004860. doi: 10.1371/journal.pgen.1004860en_US
dc.description.abstractThe common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster, indicative of conserved eukaryotic longevity effects. Studies in yeast indicate that ibuprofen destabilizes the Tat2p permease and inhibits tryptophan uptake. Loss of Tat2p increased replicative lifespan (RLS), but ibuprofen did not increase RLS when Tat2p was stabilized or in an already long-lived strain background impaired for aromatic amino acid uptake. Concomitant with lifespan extension, ibuprofen moderately reduced cell size at birth, leading to a delay in the G1 phase of the cell cycle. Similar changes in cell cycle progression were evident in a large dataset of replicatively long-lived yeast deletion strains. These results point to fundamental cell cycle signatures linked with longevity, implicate aromatic amino acid import in aging and identify a largely safe drug that extends lifespan across different kingdoms of life.en_US
dc.description.sponsorshipThe open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund.en_US
dc.rightsAttribution 3.0 United States*
dc.subjectCell cycle and cell divisionen_US
dc.subjectTOR signalingen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectAromatic amino acidsen_US
dc.subjectCaenorhabditis elegansen_US
dc.titleEnhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Importen_US

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States