Texas A&M University LibrariesTexas A&M University LibrariesTexas A&M University Libraries
    • Help
    • Login
    OAKTrust
    View Item 
    •   OAKTrust Home
    • Programs, Centers, and Institutes
    • Undergraduate Research and Capstones
    • Undergraduate Research Scholars Capstone (2006–present)
    • View Item
    •   OAKTrust Home
    • Programs, Centers, and Institutes
    • Undergraduate Research and Capstones
    • Undergraduate Research Scholars Capstone (2006–present)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    DIRECT INTERACTION OF ROTAVIRUS NON STRUCTURAL PROTEIN 4 WITH HEAT SHOCK PROTEIN 56 PROTEIN

    Thumbnail
    View/Open
    2 Moon TS w c.pdf (2.145Mb)
    Date
    2012-05-04
    Author
    Moon, Soon Young
    Metadata
    Show full item record
    Abstract
    Rotavirus (RV) causes more than 2 million diarrhea incidents and more than 600,000 deaths around the world every year. In order to prevent and treat this fatal disease, we must study, in depth, the mechanisms and pathogenesis of the individual viral proteins. It is known that RV non-structural protein 4 (NSP4) binds to several host-cell proteins, including cycophilin A and 40, which are immunophilins. In this study, we will specifically study another immunophilin/chaperone protein, Heat Shock Protein 56 (FKBP4). Previous studies suggest that FKBP4 plays an important role in transporting cholesterol from the ER to caveolae. During this study, we will use the yeast 2-hybrid assay (Y2H) to ascertain direct binding between NSP4 and FKBP4. Upon completion, other HSPs will be evaluated to gain a better understanding of the host cell interactions involved in pathogenesis of RV.
    URI
    http://hdl.handle.net/1969.1/154453
    Subject
    Rotavirus, NSP4, FKBP4
    Collections
    • Undergraduate Research Scholars Capstone (2006–present)
    Citation
    Moon, Soon Young (2012). DIRECT INTERACTION OF ROTAVIRUS NON STRUCTURAL PROTEIN 4 WITH HEAT SHOCK PROTEIN 56 PROTEIN. Honors and Undergraduate Research. Available electronically from http : / /hdl .handle .net /1969 .1 /154453.

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Advanced Search

    Browse

    All of OAKTrustCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    Statistics

    View Usage Statistics
    Help and Documentation

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV